Evolutionary impact of chimeric RNAs on generating phenotypic plasticity in human cells

Sumit Mukherjee; Milana Frenkel-Morgenstern

doi:10.1016/j.tig.2021.08.015

Evolutionary impact of chimeric RNAs on generating phenotypic plasticity in human cells

Sumit Mukherjee, Milana Frenkel-Morgenstern

Bar-Ilan University - Azrieli Faculty of Medicine

Research output: Contribution to journal › Short survey › peer-review

16 Scopus citations

Abstract

Chimeric RNAs are generated by the fusion of the exons or introns of two genes. The generation of chimeric RNAs is important for the functional expansion of cells. Here, we describe the functional implications of chimeric RNAs for generating phenotypic plasticity from an evolutionary perspective.

Original language	English
Pages (from-to)	4-7
Number of pages	4
Journal	Trends in Genetics
Volume	38
Issue number	1
Early online date	24 Sep 2021
DOIs	https://doi.org/10.1016/j.tig.2021.08.015
State	Published - Jan 2022

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Ltd

Funding

We thank the Israeli Council for Higher Education for the PBC fellowship award to Dr Sumit Mukherjee under the category of outstanding postdoctoral researchers from China and India (2019–2021). We thank members of the Cancer Genomics and Biocomputing of Complex Diseases Lab for their discussions and comments on this paper.

Funders	Funder number
Council for Higher Education

Keywords

cancer evolution
chimeric RNA
gene fusion
phenotypic plasticity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tig.2021.08.015

Cite this

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Evolutionary impact of chimeric RNAs on generating phenotypic plasticity in human cells

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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