Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes

Steven Wiltshire; Timothy M. Frayling; Andrew T. Hattersley; Graham A. Hitman; Mark Walker; Jonathan C. Levy; Stephen O'Rahilly; Christopher J. Groves; Stephan Menzel; Lon R. Cardon; Mark I. McCarthy

doi:10.1086/338760

Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes

Steven Wiltshire, Timothy M. Frayling, Andrew T. Hattersley, Graham A. Hitman, Mark Walker, Jonathan C. Levy, Stephen O'Rahilly, Christopher J. Groves, Stephan Menzel, Lon R. Cardon, Mark I. McCarthy

Research output: Contribution to journal › Article › peer-review

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Abstract

We have analyzed data from 573 pedigrees from the United Kingdom for evidence for linkage to loci influencing adult stature. Our data set comprised 1,214 diabetic and 163 nondiabetic siblings for whom height data were available. We used variance-components analysis implemented in GENEHUNTER 2 and a modification of the Haseman-Elston regression method, HE-COM. We found evidence for a locus on 3p26 (LOD score 3.17) influencing height in this adult sample, with less-significant evidence for loci on chromosomes 7, 10, 15, 17, 19, and 20. Our findings extend similar recent studies in Scandinavian and Quebecois populations, adding further evidence that height is indeed under the control of multiple genes.

Original language	English
Pages (from-to)	543-546
Number of pages	4
Journal	American Journal of Human Genetics
Volume	70
Issue number	2
DOIs	https://doi.org/10.1086/338760
State	Published - Mar 2002
Externally published	Yes

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Wiltshire, S., Frayling, T. M., Hattersley, A. T., Hitman, G. A., Walker, M., Levy, J. C., O'Rahilly, S., Groves, C. J., Menzel, S., Cardon, L. R., & McCarthy, M. I. (2002). Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes. American Journal of Human Genetics, 70(2), 543-546. https://doi.org/10.1086/338760

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abstract = "We have analyzed data from 573 pedigrees from the United Kingdom for evidence for linkage to loci influencing adult stature. Our data set comprised 1,214 diabetic and 163 nondiabetic siblings for whom height data were available. We used variance-components analysis implemented in GENEHUNTER 2 and a modification of the Haseman-Elston regression method, HE-COM. We found evidence for a locus on 3p26 (LOD score 3.17) influencing height in this adult sample, with less-significant evidence for loci on chromosomes 7, 10, 15, 17, 19, and 20. Our findings extend similar recent studies in Scandinavian and Quebecois populations, adding further evidence that height is indeed under the control of multiple genes.",

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AU - Walker, Mark

AU - Levy, Jonathan C.

AU - O'Rahilly, Stephen

AU - Groves, Christopher J.

AU - Menzel, Stephan

AU - Cardon, Lon R.

AU - McCarthy, Mark I.

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Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes

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