Evidence for a defect in NADH: Ubiquinone oxidoreductase (Complex I) in Huntington’s disease

William Davis Parker; Sally J. Boyson; Anthony S. Luder; Janice K. Parks

doi:10.1212/wnl.40.8.1231

Evidence for a defect in NADH: Ubiquinone oxidoreductase (Complex I) in Huntington’s disease

William Davis Parker
, Sally J. Boyson
, Anthony S. Luder
, Janice K. Parks

University of Colorado Anschutz Medical Campus

Research output: Contribution to journal › Article › peer-review

229 Scopus citations

Abstract

We evaluated electron transport chain activity in platelet mitochondria taken from HD patients. All 5 patients studied had striking depressions of NADH: ubiquinone oxidoreductase activity (complex I) (5.36 ± 2.91 nmol/min/mg; control mean, 19.12 ± 5.64 nmol/min/mg). Other electron transport chain activities were not significantly different from control values. HD may be caused by a mutation in 1 of the nuclear coded subunits of NADH: ubiquinone oxidoreductase.

Original language	English
Pages (from-to)	1231-1234
Number of pages	4
Journal	Neurology
Volume	40
Issue number	8
DOIs	https://doi.org/10.1212/wnl.40.8.1231
State	Published - Aug 1990
Externally published	Yes

Funding

Funders	Funder number
National Institute of Neurological Disorders and Stroke	R01NS025382

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10.1212/wnl.40.8.1231

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title = "Evidence for a defect in NADH: Ubiquinone oxidoreductase (Complex I) in Huntington{\textquoteright}s disease",

abstract = "We evaluated electron transport chain activity in platelet mitochondria taken from HD patients. All 5 patients studied had striking depressions of NADH: ubiquinone oxidoreductase activity (complex I) (5.36 ± 2.91 nmol/min/mg; control mean, 19.12 ± 5.64 nmol/min/mg). Other electron transport chain activities were not significantly different from control values. HD may be caused by a mutation in 1 of the nuclear coded subunits of NADH: ubiquinone oxidoreductase.",

author = "Parker, \{William Davis\} and Boyson, \{Sally J.\} and Luder, \{Anthony S.\} and Parks, \{Janice K.\}",

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AU - Parks, Janice K.

PY - 1990/8

Y1 - 1990/8

N2 - We evaluated electron transport chain activity in platelet mitochondria taken from HD patients. All 5 patients studied had striking depressions of NADH: ubiquinone oxidoreductase activity (complex I) (5.36 ± 2.91 nmol/min/mg; control mean, 19.12 ± 5.64 nmol/min/mg). Other electron transport chain activities were not significantly different from control values. HD may be caused by a mutation in 1 of the nuclear coded subunits of NADH: ubiquinone oxidoreductase.

AB - We evaluated electron transport chain activity in platelet mitochondria taken from HD patients. All 5 patients studied had striking depressions of NADH: ubiquinone oxidoreductase activity (complex I) (5.36 ± 2.91 nmol/min/mg; control mean, 19.12 ± 5.64 nmol/min/mg). Other electron transport chain activities were not significantly different from control values. HD may be caused by a mutation in 1 of the nuclear coded subunits of NADH: ubiquinone oxidoreductase.

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ER -

Evidence for a defect in NADH: Ubiquinone oxidoreductase (Complex I) in Huntington’s disease

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