Evaluation of the chiral DIANANE backbone as ligand for organolithium reagents

Jezabel Praz, Laure Guénée, Sarwar Aziz, Albrecht Berkessel, Alexandre Alexakis

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Novel endo,endo-2,5-diaminonorbonane-derived tertiary C 2- symmetrical diamines were synthesized via the one-pot reductive amination of enantiomerically pure norbornane-2,5-dione. These ligands were applied to various catalytic reactions such as asymmetric deprotonation, asymmetric bromine-lithium exchange, and enantioselective addition of aryl- and allkylithium reagents to aromatic aldimines.

Original languageEnglish
Pages (from-to)1780-1790
Number of pages11
JournalAdvanced Synthesis and Catalysis
Issue number9
StatePublished - 18 Jun 2012
Externally publishedYes


  • asymmetric catalysis
  • bromine-lithium exchange
  • deprotonation
  • endo,endo-2,5-diaminonorbonane derivatives
  • nucleophilic addition
  • organolithium compounds


Dive into the research topics of 'Evaluation of the chiral DIANANE backbone as ligand for organolithium reagents'. Together they form a unique fingerprint.

Cite this