Evaluation of a monoclonal antibody-based enzyme immunoassay for early detection of herpes simplex virus genital infection

J. Bornstein; E. Ben-Porath; M. Nizri; Y. Satinger; S. Sperber; H. Abramovici

Evaluation of a monoclonal antibody-based enzyme immunoassay for early detection of herpes simplex virus genital infection

J. Bornstein
, E. Ben-Porath
, M. Nizri
, Y. Satinger
, S. Sperber
, H. Abramovici

Carmel Medical Center

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A monoclonal antibody-based enzyme immunoassay test for detection of herpes simplex virus (HSV) type-common antigen was evaluated in 40 women with vulvar lesion suspicious for genital HSV infection. The assay gave interpretable readings in 90% of the cases, with sensitivity and specificity of 100% and 92% respectively, a negative predictive value of 100%, and a positive predictive value of 75%. With a few limitations, the assay may be used for early diagnosis of genital HSV infection.

Original language	English
Pages (from-to)	445-448
Number of pages	4
Journal	Israel Journal of Medical Sciences
Volume	29
Issue number	8
State	Published - Aug 1993
Externally published	Yes

Keywords

Antigen
Diagnosis
Herpes simplex virus
Labor
Monoclonal antibody
Vulvar ulcer

Cite this

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abstract = "A monoclonal antibody-based enzyme immunoassay test for detection of herpes simplex virus (HSV) type-common antigen was evaluated in 40 women with vulvar lesion suspicious for genital HSV infection. The assay gave interpretable readings in 90\% of the cases, with sensitivity and specificity of 100\% and 92\% respectively, a negative predictive value of 100\%, and a positive predictive value of 75\%. With a few limitations, the assay may be used for early diagnosis of genital HSV infection.",

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author = "J. Bornstein and E. Ben-Porath and M. Nizri and Y. Satinger and S. Sperber and H. Abramovici",

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AU - Ben-Porath, E.

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AU - Sperber, S.

AU - Abramovici, H.

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N2 - A monoclonal antibody-based enzyme immunoassay test for detection of herpes simplex virus (HSV) type-common antigen was evaluated in 40 women with vulvar lesion suspicious for genital HSV infection. The assay gave interpretable readings in 90% of the cases, with sensitivity and specificity of 100% and 92% respectively, a negative predictive value of 100%, and a positive predictive value of 75%. With a few limitations, the assay may be used for early diagnosis of genital HSV infection.

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KW - Antigen

KW - Diagnosis

KW - Herpes simplex virus

KW - Labor

KW - Monoclonal antibody

KW - Vulvar ulcer

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Evaluation of a monoclonal antibody-based enzyme immunoassay for early detection of herpes simplex virus genital infection

Abstract

Keywords

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