TY - JOUR
T1 - Estrogen receptor binding material in blood of patients after clomiphene citrate administration
T2 - Determination by a radioreceptor assay
AU - Geier, A.
AU - Lunenfeld, B.
AU - Pariente, C.
AU - Kotev-Emeth, S.
AU - Shadmi, A.
AU - Kokia, E.
AU - Blankstein, J.
PY - 1987/5
Y1 - 1987/5
N2 - The aim of the current study was to assess whether clomiphene citrate (CC) and/or active metabolites are present at presumed time of ovulation, nidation, or steroid-sensitive organogenesis, in serum of patients receiving CC for induction of ovulation. A radioreceptor assay, based on competitive replacement of 3H-estradiol on the rat uterus estrogen receptor, by ligands present in serum of patients after CC administration, was developed. Ligands reached maximal concentration 4 to 5 hours after a single dose of CC was administered, and declined with a half-life of 4.5 to 10 hours. In patients receiving CC on day 5 to day 9 in the cycle, ligands are still present on day 14 in the cycle and in some patients on day 22 of the cycle, but no ligands were detected 60 days after CC treatment.
AB - The aim of the current study was to assess whether clomiphene citrate (CC) and/or active metabolites are present at presumed time of ovulation, nidation, or steroid-sensitive organogenesis, in serum of patients receiving CC for induction of ovulation. A radioreceptor assay, based on competitive replacement of 3H-estradiol on the rat uterus estrogen receptor, by ligands present in serum of patients after CC administration, was developed. Ligands reached maximal concentration 4 to 5 hours after a single dose of CC was administered, and declined with a half-life of 4.5 to 10 hours. In patients receiving CC on day 5 to day 9 in the cycle, ligands are still present on day 14 in the cycle and in some patients on day 22 of the cycle, but no ligands were detected 60 days after CC treatment.
UR - http://www.scopus.com/inward/record.url?scp=0023236958&partnerID=8YFLogxK
U2 - 10.1016/s0015-0282(16)59164-x
DO - 10.1016/s0015-0282(16)59164-x
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C2 - 3569554
AN - SCOPUS:0023236958
SN - 0015-0282
VL - 47
SP - 778
EP - 784
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 5
ER -