Establishment and validation of an approach allowing unequivocal fetal sex determination based on placental sex-specific genes

Edgar Ontsouka; Michael Lüthi; Jonas Zaugg; Mariana Schroeder; Christiane Albrecht

doi:10.1016/j.placenta.2021.07.295

Establishment and validation of an approach allowing unequivocal fetal sex determination based on placental sex-specific genes

Edgar Ontsouka, Michael Lüthi, Jonas Zaugg, Mariana Schroeder, Christiane Albrecht

University of Bern

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The use of human placenta as a matrix for the prediction of the baby's sex has been recently documented, but evaluation methods for placental sex-determining genes allowing reliable sex prediction are still lacking. We compared the accuracy of the retrospective prediction of the baby's sex using placental mRNA expression of RPS4Y1, DDX3Y, and XIST analyzed by an already reported method and a newly developed evaluation approach. Full concordance between the predicted and the actual baby sex was only obtained when analyzing placental RPS4Y1 expression with the newly proposed method, which was found to be robust and reliable.

Original language	English
Pages (from-to)	132-134
Number of pages	3
Journal	Placenta
Volume	112
DOIs	https://doi.org/10.1016/j.placenta.2021.07.295
State	Published - 1 Sep 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2021

Funding

The current study was supported by the Swiss National Science Foundation [Grant No. 310030_149958 ] and NCCR TransCure [Grant No 51NF40-185544 ] as well as the Stiftung Lindenhof Bern [Grant No. 17-15-F ]. The authors wish to express their gratitude to the patients, physicians, and midwives from the Division of Gynecology and Obstetrics, Lindenhofgruppe, Bern, Switzerland, for participating in this study. We are grateful to Dr. Ruedi Moser-Haessig for coordinating the placenta collection at the Lindenhofspitalgruppe Bern. The current study was supported by the Swiss National Science Foundation [Grant No. 310030_149958] and NCCR TransCure [Grant No 51NF40-185544] as well as the Stiftung Lindenhof Bern [Grant No. 17-15-F]. The authors wish to express their gratitude to the patients, physicians, and midwives from the Division of Gynecology and Obstetrics, Lindenhofgruppe, Bern, Switzerland, for participating in this study. We are grateful to Dr. Ruedi Moser-Haessig for coordinating the placenta collection at the Lindenhofspitalgruppe Bern.

Funders	Funder number
Division of Gynecology and Obstetrics
NCCR	51NF40-185544, 17-15-F
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung	310030_149958

Keywords

Fetal sex
Gene expression
Human placenta
Pregnancy complications
Sex-specific genes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.placenta.2021.07.295

Cite this

@article{0167d0638a2a4160bf5f8ddd7b941534,

title = "Establishment and validation of an approach allowing unequivocal fetal sex determination based on placental sex-specific genes",

abstract = "The use of human placenta as a matrix for the prediction of the baby's sex has been recently documented, but evaluation methods for placental sex-determining genes allowing reliable sex prediction are still lacking. We compared the accuracy of the retrospective prediction of the baby's sex using placental mRNA expression of RPS4Y1, DDX3Y, and XIST analyzed by an already reported method and a newly developed evaluation approach. Full concordance between the predicted and the actual baby sex was only obtained when analyzing placental RPS4Y1 expression with the newly proposed method, which was found to be robust and reliable.",

keywords = "Fetal sex, Gene expression, Human placenta, Pregnancy complications, Sex-specific genes",

author = "Edgar Ontsouka and Michael L{\"u}thi and Jonas Zaugg and Mariana Schroeder and Christiane Albrecht",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = sep,

day = "1",

doi = "10.1016/j.placenta.2021.07.295",

language = "אנגלית",

volume = "112",

pages = "132--134",

journal = "Placenta",

issn = "0143-4004",

publisher = "W.B. Saunders Ltd",

}

TY - JOUR

T1 - Establishment and validation of an approach allowing unequivocal fetal sex determination based on placental sex-specific genes

AU - Ontsouka, Edgar

AU - Lüthi, Michael

AU - Zaugg, Jonas

AU - Schroeder, Mariana

AU - Albrecht, Christiane

PY - 2021/9/1

Y1 - 2021/9/1

N2 - The use of human placenta as a matrix for the prediction of the baby's sex has been recently documented, but evaluation methods for placental sex-determining genes allowing reliable sex prediction are still lacking. We compared the accuracy of the retrospective prediction of the baby's sex using placental mRNA expression of RPS4Y1, DDX3Y, and XIST analyzed by an already reported method and a newly developed evaluation approach. Full concordance between the predicted and the actual baby sex was only obtained when analyzing placental RPS4Y1 expression with the newly proposed method, which was found to be robust and reliable.

AB - The use of human placenta as a matrix for the prediction of the baby's sex has been recently documented, but evaluation methods for placental sex-determining genes allowing reliable sex prediction are still lacking. We compared the accuracy of the retrospective prediction of the baby's sex using placental mRNA expression of RPS4Y1, DDX3Y, and XIST analyzed by an already reported method and a newly developed evaluation approach. Full concordance between the predicted and the actual baby sex was only obtained when analyzing placental RPS4Y1 expression with the newly proposed method, which was found to be robust and reliable.

KW - Fetal sex

KW - Gene expression

KW - Human placenta

KW - Pregnancy complications

KW - Sex-specific genes

UR - http://www.scopus.com/inward/record.url?scp=85111536846&partnerID=8YFLogxK

U2 - 10.1016/j.placenta.2021.07.295

DO - 10.1016/j.placenta.2021.07.295

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 34339973

AN - SCOPUS:85111536846

SN - 0143-4004

VL - 112

SP - 132

EP - 134

JO - Placenta

JF - Placenta

ER -

Establishment and validation of an approach allowing unequivocal fetal sex determination based on placental sex-specific genes

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this