Establishment and validation of an approach allowing unequivocal fetal sex determination based on placental sex-specific genes

Edgar Ontsouka, Michael Lüthi, Jonas Zaugg, Mariana Schroeder, Christiane Albrecht

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The use of human placenta as a matrix for the prediction of the baby's sex has been recently documented, but evaluation methods for placental sex-determining genes allowing reliable sex prediction are still lacking. We compared the accuracy of the retrospective prediction of the baby's sex using placental mRNA expression of RPS4Y1, DDX3Y, and XIST analyzed by an already reported method and a newly developed evaluation approach. Full concordance between the predicted and the actual baby sex was only obtained when analyzing placental RPS4Y1 expression with the newly proposed method, which was found to be robust and reliable.

Original languageEnglish
Pages (from-to)132-134
Number of pages3
JournalPlacenta
Volume112
DOIs
StatePublished - 1 Sep 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021

Keywords

  • Fetal sex
  • Gene expression
  • Human placenta
  • Pregnancy complications
  • Sex-specific genes

Fingerprint

Dive into the research topics of 'Establishment and validation of an approach allowing unequivocal fetal sex determination based on placental sex-specific genes'. Together they form a unique fingerprint.

Cite this