Essential tremor prevalence is low in the druze population in northern israel

Judith Aharon-Peretz, Samih Badarny, Raphiq Ibrahim, Ruth Gershoni-Baruch, Gamal Hassoun

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: Essential tremor (ET) and Parkinson’s disease (PD) are probably the most common movement disorders. As ethnic differences have been reported in ET, we designed the present study to evaluate the prevalence of ET and that of Parkinson’s disease (PD) in the Druze villages of northern Israel. Methods: A two-phase, door-to-door survey was undertaken. Residents aged ≥51 years who agreed to participate and answered ‘‘yes’’ to tremor or PD-related screening questions and 3% of subjects who screened negative were evaluated. Diagnostic criteria for ET were similar to those used in Sicilian and Spanish studies. PD was diagnosed according to Gelb’s criteria. Results: The target population consisted of 9,086, the study cohort of 3,980 residents. Tremor was observed in 36 subjects. In 27, the tremor fully met the criteria for ET. The prevalence of ET (age ≥65) was 1.49% (95% CI 0.91–2.07%). PD was diagnosed in 23 subjects. The prevalence of PD (age ≥65) was 1.13 (95% CI 0.62–1.64%). Leucine-rich repeat protein kinase 2 (G2019S mutation) was evaluated in subjects diagnosed with tremor PD and those screened for assessment of the validity of the questionnaire. None carried the mutation. Discussion: The prevalence of ET in the Druze population is low and similar to the prevalence of PD.

Original languageEnglish
JournalTremor and Other Hyperkinetic Movements
Volume2
DOIs
StatePublished - 2012
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2012 Aharon-Peretz et al.

Funding

* To whom correspondence should be addressed. E-mail: [email protected] Editor: Elan D. Louis, Columbia UniversityUnited States of America Received: November 29, 2011 Accepted: December 21, 2011 Published: March 22, 2012 Copyright: ’ 2012 Aharon-Peretz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution–Noncommercial–No Derivatives License, which permits the user to copy, distribute, and transmit the work provided that the original author(s) and source are credited; that no commercial use is made of the work; and that the work is not altered or transformed. Funding: This study was supported by a research grant from the Israeli Ministry of Science and Technology. Competing Interests: The authors report no conflict of interest.

FundersFunder number
Ministry of science and technology, Israel

    Keywords

    • Druze
    • Epidemiology
    • Essential tremor
    • Leucine-rich repeat protein kinase 2
    • Parkinson’s disease

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