We propose that the mode of action of polyunsaturated essential fatty acids (PUFA) results from its effect in stabilizing and protecting the structure and functions of the neuronal membrane. PUFA's many effects include brain physiology that modulate pain, thermoregulation and sleep, and brain biochemistry that affects brain neurotransmitters, cholesterol, myelin, and cortisone. Related CNS disorders include Alzheimer's dementia, epilepsy and multiple sclerosis, which are notable for the disruption of normal cognitive behaviors. We further propose that not only will a deficiency in brain PUFA will lead to cognitive deficits, but that supplementation of PUFA can rehabilitate many of the consequent deficits. In addition, we conclude that the ratio of the two types of PUFA, viz. omega-3 and omega-6 with an optimum ratio of 1:4, is in fact even more important than the absolute level of either.
|Title of host publication
|Frontiers in Nutrition Research
|Nova Science Publishers, Inc.
|Number of pages
|Published - 2006