TY - CHAP
T1 - Essential fatty acids and cognition
AU - Yehuda, Shlomo
AU - Rabinovitz, Sharon
AU - Mostofsky, David I.
PY - 2006
Y1 - 2006
N2 - We propose that the mode of action of polyunsaturated essential fatty acids (PUFA) results from its effect in stabilizing and protecting the structure and functions of the neuronal membrane. PUFA's many effects include brain physiology that modulate pain, thermoregulation and sleep, and brain biochemistry that affects brain neurotransmitters, cholesterol, myelin, and cortisone. Related CNS disorders include Alzheimer's dementia, epilepsy and multiple sclerosis, which are notable for the disruption of normal cognitive behaviors. We further propose that not only will a deficiency in brain PUFA will lead to cognitive deficits, but that supplementation of PUFA can rehabilitate many of the consequent deficits. In addition, we conclude that the ratio of the two types of PUFA, viz. omega-3 and omega-6 with an optimum ratio of 1:4, is in fact even more important than the absolute level of either.
AB - We propose that the mode of action of polyunsaturated essential fatty acids (PUFA) results from its effect in stabilizing and protecting the structure and functions of the neuronal membrane. PUFA's many effects include brain physiology that modulate pain, thermoregulation and sleep, and brain biochemistry that affects brain neurotransmitters, cholesterol, myelin, and cortisone. Related CNS disorders include Alzheimer's dementia, epilepsy and multiple sclerosis, which are notable for the disruption of normal cognitive behaviors. We further propose that not only will a deficiency in brain PUFA will lead to cognitive deficits, but that supplementation of PUFA can rehabilitate many of the consequent deficits. In addition, we conclude that the ratio of the two types of PUFA, viz. omega-3 and omega-6 with an optimum ratio of 1:4, is in fact even more important than the absolute level of either.
UR - http://www.scopus.com/inward/record.url?scp=84895223042&partnerID=8YFLogxK
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AN - SCOPUS:84895223042
SN - 9781600211416
SP - 213
EP - 217
BT - Frontiers in Nutrition Research
PB - Nova Science Publishers, Inc.
ER -