Abstract
The purpose of this study was to examine the possible effects of a novel mixture of fatty acids, SR-3 (a specific ratio between α-linolenic and linoleic acids) on learning deficits induced by cholinergic (AF64A) and serotonergic (5,7-DHT) neurotoxins in rats. I.c.v. AF64A and 4th ventricle administration of 5,7-DHT induce severe learning deficit using the Morris Water Tank. Three weeks of treatment with SR-3 rehabilitated the learning capacity of rats. However, learning deficits induced by a lesion in area pos- trema was not rehabilitated by SR-3. The mode of action of SR-3 is unknown. We propose that this combination of free fatty acids modulates the composition of neuronal membrane lipids and allows better neuronal communication.
| Original language | English |
|---|---|
| Pages (from-to) | 511-515 |
| Number of pages | 5 |
| Journal | NeuroReport |
| Volume | 6 |
| Issue number | 3 |
| DOIs | |
| State | Published - 15 Feb 1995 |
Keywords
- 5,7-DHT
- AF64A
- Fatty acids
- Learning
- Linolcnic acid
- Linoleic acid
- Morris water maze