ERK-dependent PSD-95 induction in the gustatory cortex is necessary for taste learning, but not retrieval

Alina Elkobi, Ingrid Ehrlich, Katya Belelovsky, Liza Barki-Harrington, Kobi Rosenblum

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

The processes underlying long-term memory formation in the neocortex are poorly understood. Using taste learning, we found learning-related induction of PSD-95 in the gustatory cortex, which was temporally restricted, coupled to the learning of a novel, but not familiar, taste and controlled by ERK. Using temporally and spatially restricted RNA interference knockdown of PSD-95 in vivo, we found that PSD-95 induction is necessary for learning novel tastes, but not for the recollection of familiar ones.

Original languageEnglish
Pages (from-to)1149-1151
Number of pages3
JournalNature Neuroscience
Volume11
Issue number10
DOIs
StatePublished - Oct 2008
Externally publishedYes

Bibliographical note

Funding Information:
We thank G. Hannon (Cold Spring Harbor Laboratory) and P. Osten (Northwestern University, USA) for providing DNA vectors. We are grateful for the generous support of R. Malinow (Cold Spring Harbor Laboratory) and A. Lüthi (Friedrich Miescher Institute), in whose laboratories the lentiviruses were produced and characterized. We wish to thank A. Fine for constructive comments on the manuscript. This research was supported by the Israel Science Ffoundation and a Gene Memory Research Training Network EU grant to K.R.

Funding

We thank G. Hannon (Cold Spring Harbor Laboratory) and P. Osten (Northwestern University, USA) for providing DNA vectors. We are grateful for the generous support of R. Malinow (Cold Spring Harbor Laboratory) and A. Lüthi (Friedrich Miescher Institute), in whose laboratories the lentiviruses were produced and characterized. We wish to thank A. Fine for constructive comments on the manuscript. This research was supported by the Israel Science Ffoundation and a Gene Memory Research Training Network EU grant to K.R.

FundersFunder number
Israel Science Foundation

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