Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Fidelity of Mechanisms Governing the Cell Cycle

Mohammed El Dika, Andrew J. Fritz, Rabail H. Toor, Princess D. Rodriguez, Stephen J. Foley, Rahim Ullah, Daijing Nie, Bodhisattwa Banerjee, Dorcas Lohese, Kirsten M. Tracy, Karen C. Glass, Seth Frietze, Prachi N. Ghule, Jessica L. Heath, Anthony N. Imbalzano, Andre van Wijnen, Jonathan Gordon, Jane B. Lian, Janet L. Stein, Gary S. Stein

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The cell cycle is governed by stringent epigenetic mechanisms that, in response to intrinsic and extrinsic regulatory cues, support fidelity of DNA replication and cell division. We will focus on (1) the complex and interdependent processes that are obligatory for control of proliferation and compromised in cancer, (2) epigenetic and topological domains that are associated with distinct phases of the cell cycle that may be altered in cancer initiation and progression, and (3) the requirement for mitotic bookmarking to maintain intranuclear localization of transcriptional regulatory machinery to reinforce cell identity throughout the cell cycle to prevent malignant transformation.

Original languageEnglish
Title of host publicationResults and Problems in Cell Differentiation
PublisherSpringer Science and Business Media Deutschland GmbH
Pages375-396
Number of pages22
DOIs
StatePublished - 2022
Externally publishedYes

Publication series

NameResults and Problems in Cell Differentiation
Volume70
ISSN (Print)0080-1844
ISSN (Electronic)1861-0412

Bibliographical note

Publisher Copyright:
© 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Keywords

  • Cell cycle control
  • Chromatin
  • Epigenetic control
  • Histones
  • Mitotic gene bookmarking
  • Nuclear structure
  • Nucleosomes
  • Transcription
  • Tumor suppression

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