Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Fidelity of Mechanisms Governing the Cell Cycle

Mohammed El Dika; Andrew J. Fritz; Rabail H. Toor; Princess D. Rodriguez; Stephen J. Foley; Rahim Ullah; Daijing Nie; Bodhisattwa Banerjee; Dorcas Lohese; Kirsten M. Tracy; Karen C. Glass; Seth Frietze; Prachi N. Ghule; Jessica L. Heath; Anthony N. Imbalzano; Andre van Wijnen; Jonathan Gordon; Jane B. Lian; Janet L. Stein; Gary S. Stein

doi:10.1007/978-3-031-06573-6_13

Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Fidelity of Mechanisms Governing the Cell Cycle

Mohammed El Dika, Andrew J. Fritz, Rabail H. Toor, Princess D. Rodriguez, Stephen J. Foley, Rahim Ullah, Daijing Nie, Bodhisattwa Banerjee, Dorcas Lohese, Kirsten M. Tracy, Karen C. Glass, Seth Frietze, Prachi N. Ghule, Jessica L. Heath, Anthony N. Imbalzano, Andre van Wijnen, Jonathan Gordon, Jane B. Lian, Janet L. Stein, Gary S. Stein

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

The cell cycle is governed by stringent epigenetic mechanisms that, in response to intrinsic and extrinsic regulatory cues, support fidelity of DNA replication and cell division. We will focus on (1) the complex and interdependent processes that are obligatory for control of proliferation and compromised in cancer, (2) epigenetic and topological domains that are associated with distinct phases of the cell cycle that may be altered in cancer initiation and progression, and (3) the requirement for mitotic bookmarking to maintain intranuclear localization of transcriptional regulatory machinery to reinforce cell identity throughout the cell cycle to prevent malignant transformation.

Original language	English
Title of host publication	Results and Problems in Cell Differentiation
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	375-396
Number of pages	22
DOIs	https://doi.org/10.1007/978-3-031-06573-6_13
State	Published - 2022
Externally published	Yes

Publication series

Name	Results and Problems in Cell Differentiation
Volume	70
ISSN (Print)	0080-1844
ISSN (Electronic)	1861-0412

Bibliographical note

Publisher Copyright:
© 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Funding

This work was supported by the following funding: P01 CA240685 (GSS, JLS) U54GM115516 (GSS) R01GM129338 R01CA230618 (SF) AR039588 (GSS, JBL) DE029311 (JBL, GSS, JLS) F32CA220935 (AJF) Arthur Perelman Professorship (GSS) Charlotte Perelman Research Fund (GSS) U01CA196383 (JLS) Emily M. Lyman Pediatric Leukemia Research Fund (JH) Cartoons in Fig. 13.1 and Fig. 13.2 were created with BioRender.com, agreement # KV23AB3CM4 and ME23AB61Y8

Funders	Funder number
Charlotte Perelman Research Fund	ME23AB61Y8, KV23AB3CM4, U01CA196383
National Cancer Institute	P01CA240685
National Institute of General Medical Sciences	U54GM115516
National Institute of Arthritis and Musculoskeletal and Skin Diseases	R01AR039588
National Institute of Dental and Craniofacial Research	R01DE029311
Gips-Schüle-Stiftung

Keywords

Cell cycle control
Chromatin
Epigenetic control
Histones
Mitotic gene bookmarking
Nuclear structure
Nucleosomes
Transcription
Tumor suppression

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-031-06573-6_13

Cite this

El Dika, M., Fritz, A. J., Toor, R. H., Rodriguez, P. D., Foley, S. J., Ullah, R., Nie, D., Banerjee, B., Lohese, D., Tracy, K. M., Glass, K. C., Frietze, S., Ghule, P. N., Heath, J. L., Imbalzano, A. N., van Wijnen, A., Gordon, J., Lian, J. B., Stein, J. L., & Stein, G. S. (2022). Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Fidelity of Mechanisms Governing the Cell Cycle. In Results and Problems in Cell Differentiation (pp. 375-396). (Results and Problems in Cell Differentiation; Vol. 70). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-031-06573-6_13

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abstract = "The cell cycle is governed by stringent epigenetic mechanisms that, in response to intrinsic and extrinsic regulatory cues, support fidelity of DNA replication and cell division. We will focus on (1) the complex and interdependent processes that are obligatory for control of proliferation and compromised in cancer, (2) epigenetic and topological domains that are associated with distinct phases of the cell cycle that may be altered in cancer initiation and progression, and (3) the requirement for mitotic bookmarking to maintain intranuclear localization of transcriptional regulatory machinery to reinforce cell identity throughout the cell cycle to prevent malignant transformation.",

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doi = "10.1007/978-3-031-06573-6_13",

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El Dika, M, Fritz, AJ, Toor, RH, Rodriguez, PD, Foley, SJ, Ullah, R, Nie, D, Banerjee, B, Lohese, D, Tracy, KM, Glass, KC, Frietze, S, Ghule, PN, Heath, JL, Imbalzano, AN, van Wijnen, A, Gordon, J, Lian, JB, Stein, JL & Stein, GS 2022, Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Fidelity of Mechanisms Governing the Cell Cycle. in Results and Problems in Cell Differentiation. Results and Problems in Cell Differentiation, vol. 70, Springer Science and Business Media Deutschland GmbH, pp. 375-396. https://doi.org/10.1007/978-3-031-06573-6_13

Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Fidelity of Mechanisms Governing the Cell Cycle. / El Dika, Mohammed; Fritz, Andrew J.; Toor, Rabail H. et al.
Results and Problems in Cell Differentiation. Springer Science and Business Media Deutschland GmbH, 2022. p. 375-396 (Results and Problems in Cell Differentiation; Vol. 70).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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El Dika M, Fritz AJ, Toor RH, Rodriguez PD, Foley SJ, Ullah R et al. Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Fidelity of Mechanisms Governing the Cell Cycle. In Results and Problems in Cell Differentiation. Springer Science and Business Media Deutschland GmbH. 2022. p. 375-396. (Results and Problems in Cell Differentiation). doi: 10.1007/978-3-031-06573-6_13

Epigenetic-Mediated Regulation of Gene Expression for Biological Control and Cancer: Fidelity of Mechanisms Governing the Cell Cycle

Abstract

Publication series

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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Cite this