TY - JOUR
T1 - Epicardial adipose tissue, obesity, and the occurrence of atrial fibrillation
T2 - an overview of pathophysiology and treatment methods
AU - Scarano Pereira, Juan Pablo
AU - Owen, Eloise
AU - Martinino, Alessandro
AU - Akmal, Kiran
AU - Abouelazayem, Mohamed
AU - Graham, Yitka
AU - Weiner, Sylvia
AU - Sakran, Nasser
AU - Dekker, Lukas R.
AU - Parmar, Chetan
AU - Pouwels, Sjaak
N1 - Publisher Copyright:
© 2022 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022/4
Y1 - 2022/4
N2 - Introduction: Obesity is a chronic disease, which has significant health consequences and is a staggering burden to health care systems. Obesity can have harmful effects on the cardiovascular system, including heart failure, hypertension, coronary heart disease, and atrial fibrillation (AF). One of the possible substrates might be epicardial adipose tissue (EAT), which can be the link between AF and obesity. EAT is a fat deposit located between the myocardium and the visceral pericardium. Numerous studies have demonstrated that EAT plays a pivotal role in this relationship regarding atrial fibrillation. Areas covered: This review will focus on the role of obesity and the occurrence of atrial fibrillation (AF) and examine the connection between these and epicardial adipose tissue (EAT). The first part of this review will explain the pathophysiology of EAT and its association with the occurrence of AF. Secondly, we will review bariatric and metabolic surgery and its effects on EAT and AF. Expert commentary: In this review, the epidemiology, pathophysiology, and treatment methods of AF are explained. Secondly, the effects on EAT were elucidated. Due to the complex pathophysiological link between EAT, AF, and obesity, it is still uncertain which treatment strategy is superior.
AB - Introduction: Obesity is a chronic disease, which has significant health consequences and is a staggering burden to health care systems. Obesity can have harmful effects on the cardiovascular system, including heart failure, hypertension, coronary heart disease, and atrial fibrillation (AF). One of the possible substrates might be epicardial adipose tissue (EAT), which can be the link between AF and obesity. EAT is a fat deposit located between the myocardium and the visceral pericardium. Numerous studies have demonstrated that EAT plays a pivotal role in this relationship regarding atrial fibrillation. Areas covered: This review will focus on the role of obesity and the occurrence of atrial fibrillation (AF) and examine the connection between these and epicardial adipose tissue (EAT). The first part of this review will explain the pathophysiology of EAT and its association with the occurrence of AF. Secondly, we will review bariatric and metabolic surgery and its effects on EAT and AF. Expert commentary: In this review, the epidemiology, pathophysiology, and treatment methods of AF are explained. Secondly, the effects on EAT were elucidated. Due to the complex pathophysiological link between EAT, AF, and obesity, it is still uncertain which treatment strategy is superior.
KW - Obesity
KW - atrial fibrillation
KW - bariatric surgery
KW - epicardial adipose tissue
KW - heart rhythm disorders
KW - metabolic surgery
UR - http://www.scopus.com/inward/record.url?scp=85130022462&partnerID=8YFLogxK
U2 - 10.1080/14779072.2022.2067144
DO - 10.1080/14779072.2022.2067144
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C2 - 35443854
AN - SCOPUS:85130022462
SN - 1477-9072
VL - 20
SP - 307
EP - 322
JO - Expert Review of Cardiovascular Therapy
JF - Expert Review of Cardiovascular Therapy
IS - 4
ER -
