@article{7968f861e5714d0888bd1b87472108ed,
title = "Enzymatically incorporated genomic tags for optical mapping of DNA-binding proteins",
abstract = "All smiles: Sequence-specific methyltransferase-induced labeling of DNA (SMILing DNA) creates a fluorescence pattern of the T7 bacteriophage genome (see picture). The pattern is visualized as a linear optical barcode showing the genomic location of individual RNA polymerases bound to the DNA. The precision of the measurement presents new opportunities for contextual genomic research on the single-molecule level.",
keywords = "DNA, imaging agents, optical mapping, quantum dots, single-molecule studies",
author = "Soohong Kim and Anna Gottfried and Lin, \{Ron R.\} and Thomas Dertinger and Kim, \{Andrew S.\} and Sangyoon Chung and Colyer, \{Ryan A.\} and Elmar Weinhold and Shimon Weiss and Yuval Ebenstein",
year = "2012",
month = apr,
day = "10",
doi = "10.1002/anie.201107714",
language = "אנגלית",
volume = "51",
pages = "3578--3581",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "15",
}