Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

Maxim V. Kuleshov; Matthew R. Jones; Andrew D. Rouillard; Nicolas F. Fernandez; Qiaonan Duan; Zichen Wang; Simon Koplev; Sherry L. Jenkins; Kathleen M. Jagodnik; Alexander Lachmann; Michael G. McDermott; Caroline D. Monteiro; Gregory W. Gundersen; Avi Maayan

doi:10.1093/nar/gkw377

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

Maxim V. Kuleshov, Matthew R. Jones, Andrew D. Rouillard, Nicolas F. Fernandez, Qiaonan Duan, Zichen Wang, Simon Koplev, Sherry L. Jenkins, Kathleen M. Jagodnik, Alexander Lachmann, Michael G. McDermott, Caroline D. Monteiro, Gregory W. Gundersen, Avi Maayan

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6184 Scopus citations

Abstract

Enrichment analysis is a popular method for analyzing gene sets generated by genome-wide experiments. Here we present a significant update to one of the tools in this domain called Enrichr. Enrichr currently contains a large collection of diverse gene set libraries available for analysis and download. In total, Enrichr currently contains 180 184 annotated gene sets from 102 gene set libraries. New features have been added to Enrichr including the ability to submit fuzzy sets, upload BED files, improved application programming interface and visualization of the results as clustergrams. Overall, Enrichr is a comprehensive resource for curated gene sets and a search engine that accumulates biological knowledge for further biological discoveries. Enrichr is freely available at: http://amp.pharm.mssm.edu/Enrichr.

Original language	English
Pages (from-to)	W90-W97
Journal	Nucleic Acids Research
Volume	44
Issue number	1
DOIs	https://doi.org/10.1093/nar/gkw377
State	Published - 8 Jul 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 Oxford University Press. All rights reserved.

Funding

Funders	Funder number
Fluid Physics and Transport Processes Branch, NASA Glenn Research Center	T32 HL007824, U54 HL127624, R01 GM098316, U54 CA189201
National Heart, Lung, and Blood Institute	T32HL007824, U54HL127624
National Cancer Institute	U54CA189201
National Institute of General Medical Sciences	R01GM098316
Seventh Framework Programme	295823, 249689

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10.1093/nar/gkw377

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Kuleshov, M. V., Jones, M. R., Rouillard, A. D., Fernandez, N. F., Duan, Q., Wang, Z., Koplev, S., Jenkins, S. L., Jagodnik, K. M., Lachmann, A., McDermott, M. G., Monteiro, C. D., Gundersen, G. W., & Maayan, A. (2016). Enrichr: a comprehensive gene set enrichment analysis web server 2016 update. Nucleic Acids Research, 44(1), W90-W97. https://doi.org/10.1093/nar/gkw377

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AU - Koplev, Simon

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Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

Abstract

Bibliographical note

Funding

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