Enhancement of theophylline clearance by oral albuterol

Y. Amitai, J. Glustein, S. Godfrey

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


The possible effect of albuterol on theophylline clearance was studied in ten adult volunteers. Subjects received intravenous aminophylline loading dose (5.6 mg/kg), with oral albuterol (4 mg every 6 h), or inhaled albuterol (200 μg every 6 h), or alone (control). Theophylline levels were determined for 12-h periods. Theophylline clearance and elimination t 1/2 were calculated. Theophylline clearance was significantly higher when given with oral albuterol, in comparison with control (0.83 ± 0.05 vs 0.73 ± 0.06 ml/kg/min, p<0.02). Theophylline elimination t 1/2 was shorter with the coadministration of oral albuterol, compared with control (7.1 ± 0.3 vs. 8.1 ± 0.6 h, p<0.02). These alterations in theophylline clearance and elimination were greater in subjects who had lower control theophylline clearance. Theophylline clearance and elimination t 1/2 recorded with inhaled albuterol were not significantly different from control values. Coadministration of oral albuterol and theophylline resulted in enhancement of theophylline clearance, particularly in subjects with initially slow theophylline elimination. Such patients may require theophylline dosage adjustment as a result of this interaction.

Original languageEnglish
Pages (from-to)786-789
Number of pages4
Issue number3
StatePublished - 1992
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by Glaxo Group Research Ltd, Greenford, Middlesex, England.


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