Enhanced pharmacological activity of vitamin B12and penicillin as nanoparticles

Inbar Yariv, Anat Lipovsky, Aharon Gedanken, Rachel Lubart, Dror Fixler

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Sonochemistry has become a well-known technique for fabricating nanomaterials. Since one of the advantages of nanomaterials is that they have higher chemical activities compared with particles in the bulk form, efforts are being made to produce nano organic compounds with enhanced biological activities that could be exploited in the medical area. This study uses the sonication technique to prepare nano Vitamin B12 and nano Penicillin, and demonstrates their enhanced biological and pharmacological activity. The size and morphology of the nano Penicillin and nano Vitamin B12 were investigated using electron microscopy as well as dynamic light scattering techniques. The sizes of Penicillin and Vitamin B12 nanoparticles (NPs) were found to be 70 and 120–180 nm, respectively. The bactericidal effect of nano Penicillin was studied and found to be higher than that of the bulk form. Reducing the size of Vitamin B12 resulted in their enhanced antioxidative activity as observed using the electron paramagnetic spectroscopy technique. The penetration depth of these organic NPs can be detected by an optical iterative method. It is believed that nano organic drugs fabrication will have a great impact on the medical feld.

Original languageEnglish
Pages (from-to)3593-3601
Number of pages9
JournalInternational Journal of Nanomedicine
StatePublished - 15 May 2015

Bibliographical note

Publisher Copyright:
© 2015 Yariv et al.


  • Antibacterial
  • Antioxidant
  • Nanomaterials
  • Penicillin
  • Sonochemistry
  • Vitamin B


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