Engineering Oriented Scaffolds for Directing Neuronal Regeneration

Merav Antman-Passig, Orit Shefi

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Following nervous system injuries, such as peripheral or spinal cord injuries, severed nerves must regenerate to reinnervate tissues and restore lost-functionality. In many peripheral nerve injuries surgical intervention is required to bridge the gaps created and facilitate regrowth. The gold standard for peripheral nerve repair remains end-to-end suturing and nerve grafting, yet, these still present unmet challenges and limitation including misalignment of regenerating axons. Following spinal cord injuries currently there are no therapies capable of complete nerve restoration. Tissue engineering strategies include the design of structured tissue-like platforms to support growth and facilitate reconstructions of damaged tissues for both the peripheral and the central nervous systems. In the last two decades efforts to increase accuracy of regeneration through engineering growth-and-alignment promoting platforms have emerged as potential alternatives for grafting techniques, demonstrating advantageous effects in vitro and in vivo. This chapter reviews tissue engineering techniques and advanced fabrication strategies for oriented scaffolds and nerve repair conduits developed to aid nerve repair.

Original languageEnglish
Title of host publicationVirtual Prototyping and Bio Manufacturing in Medical Applications
PublisherSpringer International Publishing
Pages125-152
Number of pages28
ISBN (Electronic)9783030358808
ISBN (Print)9783030358792
DOIs
StatePublished - 1 Jan 2020

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media, LLC 2008.

Keywords

  • Aligned scaffolds
  • Nerve guidance channels
  • Nerve regeneration
  • Peripheral nerve repair
  • Spinal cord injury

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