Endothelial dysfunction and inflammation after percutaneous coronary intervention

Arnon Blum; David J. Schneider; Burton E. Sobel; Harold L. Dauerman

doi:10.1016/j.amjcard.2004.07.146

Endothelial dysfunction and inflammation after percutaneous coronary intervention

Arnon Blum
, David J. Schneider
, Burton E. Sobel
, Harold L. Dauerman

Poriya Medical Center
University of Vermont

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

We studied 30 consecutive patients who underwent coronary stenting with respect to postprocedure endothelial dysfunction and levels of pre- and postprocedure cytokines. Patients with severe impairment of flow-mediated dependent dilation, but not flow- mediated independent dilation, had higher concentrations of C-reactive protein before percutaneous coronary intervention (12.9 ± 20.2 vs 5.6 ± 13.0 μg/ml, p = 0.04) and 24 hours after stenting (18.8 ± 20.8 vs 11.8 ± 20.0 μg/ml, p = 0.05) than patients without severe abnormities of systemic endothelial function. Thus, endothelium-dependent dilation abnormalities were related to the systemic inflammatory state, whereas endothelium-independent dilation abnormalities were not related to the inflammatory status of the patient.

Original language	English
Pages (from-to)	1420-1423
Number of pages	4
Journal	American Journal of Cardiology
Volume	94
Issue number	11
DOIs	https://doi.org/10.1016/j.amjcard.2004.07.146
State	Published - 1 Dec 2004
Externally published	Yes

Bibliographical note

Funding Information:
This study was supported by Grant RR-109 from the University of Vermont General Clinical Research Center, Burlington, Vermont, and by a grant from Boston Scientific, Inc., Natick, Massachusetts.

Funding

This study was supported by Grant RR-109 from the University of Vermont General Clinical Research Center, Burlington, Vermont, and by a grant from Boston Scientific, Inc., Natick, Massachusetts.

Funders
Boston Scientific, Inc.
University of Vermont General Clinical Research Center

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10.1016/j.amjcard.2004.07.146

Cite this

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title = "Endothelial dysfunction and inflammation after percutaneous coronary intervention",

abstract = "We studied 30 consecutive patients who underwent coronary stenting with respect to postprocedure endothelial dysfunction and levels of pre- and postprocedure cytokines. Patients with severe impairment of flow-mediated dependent dilation, but not flow- mediated independent dilation, had higher concentrations of C-reactive protein before percutaneous coronary intervention (12.9 ± 20.2 vs 5.6 ± 13.0 μg/ml, p = 0.04) and 24 hours after stenting (18.8 ± 20.8 vs 11.8 ± 20.0 μg/ml, p = 0.05) than patients without severe abnormities of systemic endothelial function. Thus, endothelium-dependent dilation abnormalities were related to the systemic inflammatory state, whereas endothelium-independent dilation abnormalities were not related to the inflammatory status of the patient.",

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note = "Funding Information: This study was supported by Grant RR-109 from the University of Vermont General Clinical Research Center, Burlington, Vermont, and by a grant from Boston Scientific, Inc., Natick, Massachusetts. ",

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AU - Schneider, David J.

AU - Sobel, Burton E.

AU - Dauerman, Harold L.

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AB - We studied 30 consecutive patients who underwent coronary stenting with respect to postprocedure endothelial dysfunction and levels of pre- and postprocedure cytokines. Patients with severe impairment of flow-mediated dependent dilation, but not flow- mediated independent dilation, had higher concentrations of C-reactive protein before percutaneous coronary intervention (12.9 ± 20.2 vs 5.6 ± 13.0 μg/ml, p = 0.04) and 24 hours after stenting (18.8 ± 20.8 vs 11.8 ± 20.0 μg/ml, p = 0.05) than patients without severe abnormities of systemic endothelial function. Thus, endothelium-dependent dilation abnormalities were related to the systemic inflammatory state, whereas endothelium-independent dilation abnormalities were not related to the inflammatory status of the patient.

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Endothelial dysfunction and inflammation after percutaneous coronary intervention

Abstract

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