We studied 30 consecutive patients who underwent coronary stenting with respect to postprocedure endothelial dysfunction and levels of pre- and postprocedure cytokines. Patients with severe impairment of flow-mediated dependent dilation, but not flow- mediated independent dilation, had higher concentrations of C-reactive protein before percutaneous coronary intervention (12.9 ± 20.2 vs 5.6 ± 13.0 μg/ml, p = 0.04) and 24 hours after stenting (18.8 ± 20.8 vs 11.8 ± 20.0 μg/ml, p = 0.05) than patients without severe abnormities of systemic endothelial function. Thus, endothelium-dependent dilation abnormalities were related to the systemic inflammatory state, whereas endothelium-independent dilation abnormalities were not related to the inflammatory status of the patient.
Bibliographical noteFunding Information:
This study was supported by Grant RR-109 from the University of Vermont General Clinical Research Center, Burlington, Vermont, and by a grant from Boston Scientific, Inc., Natick, Massachusetts.