Endothelial dysfunction and inflammation after percutaneous coronary intervention

Arnon Blum, David J. Schneider, Burton E. Sobel, Harold L. Dauerman

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


We studied 30 consecutive patients who underwent coronary stenting with respect to postprocedure endothelial dysfunction and levels of pre- and postprocedure cytokines. Patients with severe impairment of flow-mediated dependent dilation, but not flow- mediated independent dilation, had higher concentrations of C-reactive protein before percutaneous coronary intervention (12.9 ± 20.2 vs 5.6 ± 13.0 μg/ml, p = 0.04) and 24 hours after stenting (18.8 ± 20.8 vs 11.8 ± 20.0 μg/ml, p = 0.05) than patients without severe abnormities of systemic endothelial function. Thus, endothelium-dependent dilation abnormalities were related to the systemic inflammatory state, whereas endothelium-independent dilation abnormalities were not related to the inflammatory status of the patient.

Original languageEnglish
Pages (from-to)1420-1423
Number of pages4
JournalAmerican Journal of Cardiology
Issue number11
StatePublished - 1 Dec 2004
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by Grant RR-109 from the University of Vermont General Clinical Research Center, Burlington, Vermont, and by a grant from Boston Scientific, Inc., Natick, Massachusetts.


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