Endogenous serotonin stimulates striatal dopamine release in conscious rats

G. Yadid; K. Pacak; I. J. Kopin; D. S. Goldstein

doi:10.1016/s0022-3565(25)22522-8

Endogenous serotonin stimulates striatal dopamine release in conscious rats

G. Yadid
, K. Pacak
, I. J. Kopin
, D. S. Goldstein

National Institutes of Health

Research output: Contribution to journal › Article › peer-review

104 Scopus citations

Abstract

Serotonin (5-HT) and dopamine (DA) are established neurotransmitters in the brain. This study examined whether, in conscious, free-moving rats, increased concentrations of endogenous 5-HT in extracellular fluid of the corpus striatum affect local release of endogenous DA. Administration of the 5-HT reuptake blocker alaproclate via a microdialysis probe increased striatal dialysate levels of DA and its metabolites dihydroxyphenylacetic acid and homovanillic acid as well as levels of 5-HT and of the 5-HT metabolite 5-hydroxyindoleacetic acid. Whereas DA reuptake blockade with GBR- 12909 did not prevent these effects of alaproclate, serotonergic ablation by i.c.v. administration of 5,7-dihydroxytryptamine markedly decreased basal levels of 5-HT and 5-hydroxyindoleacetic acid and abolished the effects of alaproclate on dialysate levels of DA, 5-HT and their metabolites. The results are consistent with a stimulatory action of endogenous 5-HT on striatal DA release in conscious animals.

Original language	English
Pages (from-to)	1158-1165
Number of pages	8
Journal	Journal of Pharmacology and Experimental Therapeutics
Volume	270
Issue number	3
DOIs	https://doi.org/10.1016/s0022-3565(25)22522-8
State	Published - Sep 1994
Externally published	Yes

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10.1016/s0022-3565(25)22522-8

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title = "Endogenous serotonin stimulates striatal dopamine release in conscious rats",

abstract = "Serotonin (5-HT) and dopamine (DA) are established neurotransmitters in the brain. This study examined whether, in conscious, free-moving rats, increased concentrations of endogenous 5-HT in extracellular fluid of the corpus striatum affect local release of endogenous DA. Administration of the 5-HT reuptake blocker alaproclate via a microdialysis probe increased striatal dialysate levels of DA and its metabolites dihydroxyphenylacetic acid and homovanillic acid as well as levels of 5-HT and of the 5-HT metabolite 5-hydroxyindoleacetic acid. Whereas DA reuptake blockade with GBR- 12909 did not prevent these effects of alaproclate, serotonergic ablation by i.c.v. administration of 5,7-dihydroxytryptamine markedly decreased basal levels of 5-HT and 5-hydroxyindoleacetic acid and abolished the effects of alaproclate on dialysate levels of DA, 5-HT and their metabolites. The results are consistent with a stimulatory action of endogenous 5-HT on striatal DA release in conscious animals.",

author = "G. Yadid and K. Pacak and Kopin, \{I. J.\} and Goldstein, \{D. S.\}",

year = "1994",

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doi = "10.1016/s0022-3565(25)22522-8",

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T1 - Endogenous serotonin stimulates striatal dopamine release in conscious rats

AU - Yadid, G.

AU - Pacak, K.

AU - Kopin, I. J.

AU - Goldstein, D. S.

PY - 1994/9

Y1 - 1994/9

N2 - Serotonin (5-HT) and dopamine (DA) are established neurotransmitters in the brain. This study examined whether, in conscious, free-moving rats, increased concentrations of endogenous 5-HT in extracellular fluid of the corpus striatum affect local release of endogenous DA. Administration of the 5-HT reuptake blocker alaproclate via a microdialysis probe increased striatal dialysate levels of DA and its metabolites dihydroxyphenylacetic acid and homovanillic acid as well as levels of 5-HT and of the 5-HT metabolite 5-hydroxyindoleacetic acid. Whereas DA reuptake blockade with GBR- 12909 did not prevent these effects of alaproclate, serotonergic ablation by i.c.v. administration of 5,7-dihydroxytryptamine markedly decreased basal levels of 5-HT and 5-hydroxyindoleacetic acid and abolished the effects of alaproclate on dialysate levels of DA, 5-HT and their metabolites. The results are consistent with a stimulatory action of endogenous 5-HT on striatal DA release in conscious animals.

AB - Serotonin (5-HT) and dopamine (DA) are established neurotransmitters in the brain. This study examined whether, in conscious, free-moving rats, increased concentrations of endogenous 5-HT in extracellular fluid of the corpus striatum affect local release of endogenous DA. Administration of the 5-HT reuptake blocker alaproclate via a microdialysis probe increased striatal dialysate levels of DA and its metabolites dihydroxyphenylacetic acid and homovanillic acid as well as levels of 5-HT and of the 5-HT metabolite 5-hydroxyindoleacetic acid. Whereas DA reuptake blockade with GBR- 12909 did not prevent these effects of alaproclate, serotonergic ablation by i.c.v. administration of 5,7-dihydroxytryptamine markedly decreased basal levels of 5-HT and 5-hydroxyindoleacetic acid and abolished the effects of alaproclate on dialysate levels of DA, 5-HT and their metabolites. The results are consistent with a stimulatory action of endogenous 5-HT on striatal DA release in conscious animals.

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JF - Journal of Pharmacology and Experimental Therapeutics

IS - 3

ER -

Endogenous serotonin stimulates striatal dopamine release in conscious rats

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