TY - JOUR
T1 - Endogenous serotonin stimulates striatal dopamine release in conscious rats
AU - Yadid, G.
AU - Pacak, K.
AU - Kopin, I. J.
AU - Goldstein, D. S.
PY - 1994/9
Y1 - 1994/9
N2 - Serotonin (5-HT) and dopamine (DA) are established neurotransmitters in the brain. This study examined whether, in conscious, free-moving rats, increased concentrations of endogenous 5-HT in extracellular fluid of the corpus striatum affect local release of endogenous DA. Administration of the 5-HT reuptake blocker alaproclate via a microdialysis probe increased striatal dialysate levels of DA and its metabolites dihydroxyphenylacetic acid and homovanillic acid as well as levels of 5-HT and of the 5-HT metabolite 5-hydroxyindoleacetic acid. Whereas DA reuptake blockade with GBR- 12909 did not prevent these effects of alaproclate, serotonergic ablation by i.c.v. administration of 5,7-dihydroxytryptamine markedly decreased basal levels of 5-HT and 5-hydroxyindoleacetic acid and abolished the effects of alaproclate on dialysate levels of DA, 5-HT and their metabolites. The results are consistent with a stimulatory action of endogenous 5-HT on striatal DA release in conscious animals.
AB - Serotonin (5-HT) and dopamine (DA) are established neurotransmitters in the brain. This study examined whether, in conscious, free-moving rats, increased concentrations of endogenous 5-HT in extracellular fluid of the corpus striatum affect local release of endogenous DA. Administration of the 5-HT reuptake blocker alaproclate via a microdialysis probe increased striatal dialysate levels of DA and its metabolites dihydroxyphenylacetic acid and homovanillic acid as well as levels of 5-HT and of the 5-HT metabolite 5-hydroxyindoleacetic acid. Whereas DA reuptake blockade with GBR- 12909 did not prevent these effects of alaproclate, serotonergic ablation by i.c.v. administration of 5,7-dihydroxytryptamine markedly decreased basal levels of 5-HT and 5-hydroxyindoleacetic acid and abolished the effects of alaproclate on dialysate levels of DA, 5-HT and their metabolites. The results are consistent with a stimulatory action of endogenous 5-HT on striatal DA release in conscious animals.
UR - https://www.scopus.com/pages/publications/0028149785
U2 - 10.1016/s0022-3565(25)22522-8
DO - 10.1016/s0022-3565(25)22522-8
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 7932166
AN - SCOPUS:0028149785
SN - 0022-3565
VL - 270
SP - 1158
EP - 1165
JO - Journal of Pharmacology and Experimental Therapeutics
JF - Journal of Pharmacology and Experimental Therapeutics
IS - 3
ER -