Endogenous cholecystokinin reduces feeding in young rats

Aron Weller, Gerard P. Smith, James Gibbs

Research output: Contribution to journalArticlepeer-review

115 Scopus citations


The hypothesis that endogenous cholecystokinin (CCK) released from the small intestine during feeding causes satiety was tested in rat pups, 9 to 12 days old. Intragastric administration of soybean trypsin inhibitor, a procedure that releases CCK from the small intestine, decreased the subsequent intake of a test meal. This effect was reversed by prior treatment with MK-329, a selective antagonist of CCK at alimentary-type CCK (CCK-A) receptors. Thus, endogenous, small intestinal CCK can cause satiety in the neonatal rat and this effect involves CCK-A receptors.

Original languageEnglish
Pages (from-to)1589-1591
Number of pages3
Issue number4950
StatePublished - 30 Mar 1990


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