Abstract
The hypothesis that endogenous cholecystokinin (CCK) released from the small intestine during feeding causes satiety was tested in rat pups, 9 to 12 days old. Intragastric administration of soybean trypsin inhibitor, a procedure that releases CCK from the small intestine, decreased the subsequent intake of a test meal. This effect was reversed by prior treatment with MK-329, a selective antagonist of CCK at alimentary-type CCK (CCK-A) receptors. Thus, endogenous, small intestinal CCK can cause satiety in the neonatal rat and this effect involves CCK-A receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 1589-1591 |
| Number of pages | 3 |
| Journal | Science |
| Volume | 247 |
| Issue number | 4950 |
| State | Published - 30 Mar 1990 |