Abstract
Purpose: To investigate and to identify endocrine and metabolic abnormalities in patients with central serous chorioretinopathy (CSCR). Design: Observational case series. Participants: Twenty-four patients with CSCR. Methods: Serum and urinary catecholamines, glucocorticoids, mineralocorticoids, serum testosterone, and thyroid-stimulating hormone (TSH) function were evaluated prospectively. Results: Fifty percent (12 of 24) of patients with active acute CSCR showed elevated 24-hour urine cortisol or tetrahydroaldosterone levels. Serum aldosterone levels were low in 7 of 24 (29.1%) patients. Single morning plasma catecholamine levels were elevated in 7 of 24 patients, although 24-hour urine metanephrines (catecholamine breakdown products) were normal. Serum testosterone and TSH levels were normal in nearly all (23 of 24) patients. Conclusion: Many patients with acute CSCR have elevated 24-hour urine corticosteroids, which may contribute to the pathogenesis of the disorder. Endogenous mineralocorticoid dysfunction is a newly described feature of CSCR.
Original language | English |
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Pages (from-to) | 698-703 |
Number of pages | 6 |
Journal | Ophthalmology |
Volume | 110 |
Issue number | 4 |
DOIs | |
State | Published - 1 Apr 2003 |
Externally published | Yes |
Bibliographical note
Funding Information:Supported by The Macula Foundation, New York, New York, and The Richard H. Chartrand Foundation, San Francisco, California. Additional support was received from Research to Prevent Blindness, New York, New York, and The Massachusetts Lions Eye Research Fund Inc., New Bedford, Massachusetts.
Funding
Supported by The Macula Foundation, New York, New York, and The Richard H. Chartrand Foundation, San Francisco, California. Additional support was received from Research to Prevent Blindness, New York, New York, and The Massachusetts Lions Eye Research Fund Inc., New Bedford, Massachusetts.
Funders | Funder number |
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Research to Prevent Blindness, New York, New York, and The Massachusetts Lions Eye Research Fund Inc., New Bedford | |
Macula Foundation, New York, New York |