Endocrine abnormalities in patients with central serous chorioretinopathy

Robert Haimovici, Shimon Rumelt, James Melby

Research output: Contribution to journalArticlepeer-review

138 Scopus citations

Abstract

Purpose: To investigate and to identify endocrine and metabolic abnormalities in patients with central serous chorioretinopathy (CSCR). Design: Observational case series. Participants: Twenty-four patients with CSCR. Methods: Serum and urinary catecholamines, glucocorticoids, mineralocorticoids, serum testosterone, and thyroid-stimulating hormone (TSH) function were evaluated prospectively. Results: Fifty percent (12 of 24) of patients with active acute CSCR showed elevated 24-hour urine cortisol or tetrahydroaldosterone levels. Serum aldosterone levels were low in 7 of 24 (29.1%) patients. Single morning plasma catecholamine levels were elevated in 7 of 24 patients, although 24-hour urine metanephrines (catecholamine breakdown products) were normal. Serum testosterone and TSH levels were normal in nearly all (23 of 24) patients. Conclusion: Many patients with acute CSCR have elevated 24-hour urine corticosteroids, which may contribute to the pathogenesis of the disorder. Endogenous mineralocorticoid dysfunction is a newly described feature of CSCR.

Original languageEnglish
Pages (from-to)698-703
Number of pages6
JournalOphthalmology
Volume110
Issue number4
DOIs
StatePublished - 1 Apr 2003
Externally publishedYes

Bibliographical note

Funding Information:
Supported by The Macula Foundation, New York, New York, and The Richard H. Chartrand Foundation, San Francisco, California. Additional support was received from Research to Prevent Blindness, New York, New York, and The Massachusetts Lions Eye Research Fund Inc., New Bedford, Massachusetts.

Funding

Supported by The Macula Foundation, New York, New York, and The Richard H. Chartrand Foundation, San Francisco, California. Additional support was received from Research to Prevent Blindness, New York, New York, and The Massachusetts Lions Eye Research Fund Inc., New Bedford, Massachusetts.

FundersFunder number
Research to Prevent Blindness, New York, New York, and The Massachusetts Lions Eye Research Fund Inc., New Bedford
Macula Foundation, New York, New York

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