Enantioselective separation using chiral mesoporous spherical silica prepared by templating of chiral block copolymers

Pradip Paik, Aharon Gedanken, Yitzhak Mastai

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

In this work, we synthesized chiral mesoporous silica (CMS) spheres, which can be used as a potential candidate for chiral separation. The CMS spheres with controllable pore sizes (of 2-3 nm) and high surface areas of ca. 614 m 2 g -1 were synthesized by chiral templating with chiral block copolymers based on poly(ethylene oxide) and dl-glutamic acid [PEO 113-b-(GluA) 10]. The ordered structure of the chiral mesopores was characterized by high-resolution transmission electron microscopy, and the average pore diameters of chiral mesopores were estimated from the nitrogen adsorption-desorption measurements. The enantioselectivity properties and chiral resolution kinetics of the mesopores of silica spheres, after extraction of chiral polymers of PEO 113-b-(l/d-GluA) 10, were scrutinized using a racemic solution of valine and measuring the circular dichroism and optical polarimetery. A chiral selectivity factor of 5.22 was found with a specific enantiomer of valine adsorbed preferably. These results raise the new possibilities of CMS spheres for enantiomeric separation and other enantioselective applications.

Original languageEnglish
Pages (from-to)1834-1842
Number of pages9
JournalACS Applied Materials and Interfaces
Volume1
Issue number8
DOIs
StatePublished - 26 Aug 2009

Keywords

  • chiral block copolymers
  • chiral mesopores
  • enantiomeric separation
  • silica spheres

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