Emerging Roles of Extracellular Vesicles Derived Non-Coding RNAs in the Cardiovascular System

Ramasamy Subbiah, Divya Sridharan, Karthika Duairaj, K. Shanmugha Rajan, Mahmood Khan, Venkata Naga Srikanth Garikipati

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Cardiovascular disease is the leading cause of morbidity and mortality all over the world. Emerging evidence emphasize the importance of extracellular vesicles (EVs) in the cell to cell communication in the cardiovascular system which is majorly mediated through non-coding RNA cargo. Advancement in sequencing technologies revealed a major proportion of human genome is composed of non-coding RNAs viz., miRNAs, lncRNAs, tRNAs, snoRNAs, piRNAs and rRNAs. However, our understanding of the role of ncRNAs-containing EVs in cardiovascular health and disease is still in its infancy. This book chapter provides a comprehensive update on our understanding on the role of EVs derived ncRNAs in the cardiovascular pathophysiology and their therapeutic potential.

Original languageEnglish
Title of host publicationSubcellular Biochemistry
PublisherSpringer Science and Business Media B.V.
Pages437-453
Number of pages17
DOIs
StatePublished - 2021

Publication series

NameSubcellular Biochemistry
Volume97
ISSN (Print)0306-0225

Bibliographical note

Publisher Copyright:
© 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Keywords

  • Cardiovascular disease
  • Extracellular Vesicles
  • circular RNA
  • lncRNA
  • miRNA

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