Abstract
Cardiovascular disease is the leading cause of morbidity and mortality all over the world. Emerging evidence emphasize the importance of extracellular vesicles (EVs) in the cell to cell communication in the cardiovascular system which is majorly mediated through non-coding RNA cargo. Advancement in sequencing technologies revealed a major proportion of human genome is composed of non-coding RNAs viz., miRNAs, lncRNAs, tRNAs, snoRNAs, piRNAs and rRNAs. However, our understanding of the role of ncRNAs-containing EVs in cardiovascular health and disease is still in its infancy. This book chapter provides a comprehensive update on our understanding on the role of EVs derived ncRNAs in the cardiovascular pathophysiology and their therapeutic potential.
| Original language | English |
|---|---|
| Title of host publication | Subcellular Biochemistry |
| Publisher | Springer Science and Business Media B.V. |
| Pages | 437-453 |
| Number of pages | 17 |
| DOIs | |
| State | Published - 2021 |
Publication series
| Name | Subcellular Biochemistry |
|---|---|
| Volume | 97 |
| ISSN (Print) | 0306-0225 |
Bibliographical note
Publisher Copyright:© 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.
Funding
We apologize to those whose original work could not be cited owing to space limitations. This work was partially supported by American Heart Association Career Development Award 18CDA34110277 and startup funds from the Ohio State University Medical Center to VNSG. This work was also supported by the National Heart Lung and Blood InstituteHL136232 to MK.
| Funders | Funder number |
|---|---|
| Ohio State University Medical Center | |
| National Heart, Lung, and Blood Institute | |
| American Heart Association | 18CDA34110277 |
Keywords
- Cardiovascular disease
- Extracellular Vesicles
- circular RNA
- lncRNA
- miRNA
