Emerging role of chimeric rnas in cell plasticity and adaptive evolution of cancer cells

Sumit Mukherjee; Henry H. Heng; Milana Frenkel-Morgenstern

doi:10.3390/cancers13174328

Emerging role of chimeric rnas in cell plasticity and adaptive evolution of cancer cells

Sumit Mukherjee, Henry H. Heng, Milana Frenkel-Morgenstern

Bar-Ilan University - Azrieli Faculty of Medicine

Wayne State University

Research output: Contribution to journal › Review article › peer-review

14 Scopus citations

Abstract

Gene fusions can give rise to somatic alterations in cancers. Fusion genes have the potential to create chimeric RNAs, which can generate the phenotypic diversity of cancer cells, and could be associated with novel molecular functions related to cancer cell survival and proliferation. The expression of chimeric RNAs in cancer cells might impact diverse cancer-related functions, including loss of apoptosis and cancer cell plasticity, and promote oncogenesis. Due to their recurrence in cancers and functional association with oncogenic processes, chimeric RNAs are considered biomarkers for cancer diagnosis. Several recent studies demonstrated that chimeric RNAs could lead to the generation of new functionality for the resistance of cancer cells against drug therapy. Therefore, targeting chimeric RNAs in drug resistance cancer could be useful for developing precision medicine. So, understanding the functional impact of chimeric RNAs in cancer cells from an evolutionary perspective will be helpful to elucidate cancer evolution, which could provide a new insight to design more effective therapies for cancer patients in a personalized manner.

Original language	English
Article number	4328
Journal	Cancers
Volume	13
Issue number	17
DOIs	https://doi.org/10.3390/cancers13174328
State	Published - 27 Aug 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Funding

Funding: S.M. was supported by the Israeli Council for Higher Education through the PBC fellowship program for outstanding postdoctoral researchers from China and India (2019–2021). M.F-M. was supported by the Israel Innovation Authority (KAMIN Grant No.: 66824, 2019–2021) and COVID-19 Data Science Institute (DSI) grant, Bar-Ilan University (Grant No.: 247017, 2020–2021).

Funders	Funder number
COVID-19 Data Science Institute
Israel Innovation Authority
KAMIN	66824
Bar-Ilan University	247017
Council for Higher Education
Defence Science Institute

Keywords

Cancer evolution
Cellular plasticity
Chimeric RNAs
Genomic instability

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/cancers13174328

Cite this

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abstract = "Gene fusions can give rise to somatic alterations in cancers. Fusion genes have the potential to create chimeric RNAs, which can generate the phenotypic diversity of cancer cells, and could be associated with novel molecular functions related to cancer cell survival and proliferation. The expression of chimeric RNAs in cancer cells might impact diverse cancer-related functions, including loss of apoptosis and cancer cell plasticity, and promote oncogenesis. Due to their recurrence in cancers and functional association with oncogenic processes, chimeric RNAs are considered biomarkers for cancer diagnosis. Several recent studies demonstrated that chimeric RNAs could lead to the generation of new functionality for the resistance of cancer cells against drug therapy. Therefore, targeting chimeric RNAs in drug resistance cancer could be useful for developing precision medicine. So, understanding the functional impact of chimeric RNAs in cancer cells from an evolutionary perspective will be helpful to elucidate cancer evolution, which could provide a new insight to design more effective therapies for cancer patients in a personalized manner.",

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Emerging role of chimeric rnas in cell plasticity and adaptive evolution of cancer cells

Abstract

Bibliographical note

Funding

Keywords

UN SDGs

Access to Document

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