TY - JOUR
T1 - Emerging cardiac non-coding landscape
T2 - The importance of meta-analysis
AU - Rajan, K. Shanmugha
AU - Ramasamy, Subbiah
AU - George-William, J. N.
AU - Rajendhran, Jeyaprakash
N1 - Publisher Copyright:
© 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM)
PY - 2017/2/1
Y1 - 2017/2/1
N2 - The invention of transcriptome-wide deep sequencing technology has fundamentally changed our understanding of the complex networks that mediate cardiac functions. Since its inception, researchers have uncovered various novel pathways and transcripts that could be one day used for therapeutics and diagnostics. The characterization of various non-protein coding RNAs (ncRNAs) has aided the study of cardiac manifestation in more detail. Although numerous studies have unearthed the importance of miRNA and lncRNA, the existence and importance of other ncRNAs have been neglected due to their unusual behaviors and outdated ideologies. Recent studies focused on these neglected molecules have proven that these molecules are functional and of great potential. This review brings into focus some of those ncRNAs that were once thought to be futile and not expressed in the heart with an emphasis on the use of meta-data.
AB - The invention of transcriptome-wide deep sequencing technology has fundamentally changed our understanding of the complex networks that mediate cardiac functions. Since its inception, researchers have uncovered various novel pathways and transcripts that could be one day used for therapeutics and diagnostics. The characterization of various non-protein coding RNAs (ncRNAs) has aided the study of cardiac manifestation in more detail. Although numerous studies have unearthed the importance of miRNA and lncRNA, the existence and importance of other ncRNAs have been neglected due to their unusual behaviors and outdated ideologies. Recent studies focused on these neglected molecules have proven that these molecules are functional and of great potential. This review brings into focus some of those ncRNAs that were once thought to be futile and not expressed in the heart with an emphasis on the use of meta-data.
KW - Cardiology
KW - Meta-analysis
KW - Non-coding RNA
KW - piRNA
KW - snoRNA
UR - http://www.scopus.com/inward/record.url?scp=85007524609&partnerID=8YFLogxK
U2 - 10.1016/j.biochi.2016.12.018
DO - 10.1016/j.biochi.2016.12.018
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C2 - 28038934
AN - SCOPUS:85007524609
SN - 0300-9084
VL - 133
SP - 87
EP - 94
JO - Biochimie
JF - Biochimie
ER -