Emerging cardiac non-coding landscape: The importance of meta-analysis

K. Shanmugha Rajan; Subbiah Ramasamy; J. N. George-William; Jeyaprakash Rajendhran

doi:10.1016/j.biochi.2016.12.018

Emerging cardiac non-coding landscape: The importance of meta-analysis

K. Shanmugha Rajan, Subbiah Ramasamy, J. N. George-William, Jeyaprakash Rajendhran

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

The invention of transcriptome-wide deep sequencing technology has fundamentally changed our understanding of the complex networks that mediate cardiac functions. Since its inception, researchers have uncovered various novel pathways and transcripts that could be one day used for therapeutics and diagnostics. The characterization of various non-protein coding RNAs (ncRNAs) has aided the study of cardiac manifestation in more detail. Although numerous studies have unearthed the importance of miRNA and lncRNA, the existence and importance of other ncRNAs have been neglected due to their unusual behaviors and outdated ideologies. Recent studies focused on these neglected molecules have proven that these molecules are functional and of great potential. This review brings into focus some of those ncRNAs that were once thought to be futile and not expressed in the heart with an emphasis on the use of meta-data.

Original language	English
Pages (from-to)	87-94
Number of pages	8
Journal	Biochimie
Volume	133
DOIs	https://doi.org/10.1016/j.biochi.2016.12.018
State	Published - 1 Feb 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2016 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM)

Funding

Authors duly acknowledged DBT (BT/PR 15077/GBD/27/300/2011, BT/PR/10547/AAQ/3/673/2014 and SERB (SR/FT/LS-48/2011, EMR/2014/000892) Govt. of India for their funding support. KSR performed the meta-analysis while being at Cardiac Hypertrophy Laboratory, Madurai Kamaraj University, Tamilnadu, India. KSR is currently supported by the “The Mina and Everard Goodman Faculty of Life Sciences Master's Degree Fellowship”, Bar-Ilan University, Israel.

Funders	Funder number
Cardiac Hypertrophy Laboratory
Department of Biotechnology, Ministry of Science and Technology, India	BT/PR/10547/AAQ/3/673/2014, BT/PR 15077/GBD/27/300/2011
Science and Engineering Research Board	EMR/2014/000892, SR/FT/LS-48/2011
Bar-Ilan University
Madurai Kamaraj University

Keywords

Cardiology
Meta-analysis
Non-coding RNA
piRNA
snoRNA

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10.1016/j.biochi.2016.12.018

Cite this

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Emerging cardiac non-coding landscape: The importance of meta-analysis

Abstract

Bibliographical note

Funding

Keywords

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