Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022

Neta S. Zuckerman; Itay Bar-Or; Danit Sofer; Efrat Bucris; Hagar Morad; Lester M. Shulman; Nofar Levi; Leah Weiss; Irina Aguvaev; Zvi Cohen; Klil Kestin; Rinat Vasserman; Michal Elul; Ilana S. Fratty; Miranda Geva; Marina Wax; Oran Erster; Ruth Yishai; Lior Hecht-Sagie; Sharon Alroy-Preis; Ella Mendelson; Merav Weil

doi:10.2807/1560-7917.ES.2022.27.37.2200694

Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022

Neta S. Zuckerman, Itay Bar-Or, Danit Sofer, Efrat Bucris, Hagar Morad, Lester M. Shulman, Nofar Levi, Leah Weiss, Irina Aguvaev, Zvi Cohen, Klil Kestin, Rinat Vasserman, Michal Elul, Ilana S. Fratty, Miranda Geva, Marina Wax, Oran Erster, Ruth Yishai, Lior Hecht-Sagie, Sharon Alroy-PreisElla Mendelson, Merav Weil

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We report an emergence and increase in poliovirus type 2 detection via routine wastewater surveillance in three non-overlapping regions in the Jerusalem region, Israel, between April and July 2022. Sequencing showed genetic linkage among isolates and accumulation of mutations over time, with two isolates defined as vaccine-derived polioviruses (VDPV). This demonstrates the emergence and potential circulation of type 2 VDPV in a high-income country with high vaccine coverage and underscores the importance of routine wastewater surveillance during the polio eradication.

Original language	English
Article number	2200694
Journal	Eurosurveillance
Volume	27
Issue number	37
DOIs	https://doi.org/10.2807/1560-7917.ES.2022.27.37.2200694
State	Published - 15 Sep 2022
Externally published	Yes

Bibliographical note

Funding Information:
We wish to acknowledge the hard work done by the Public Health Services (Israeli Ministry of Health): Epidemiology Division, Environmental department and the Jerusalem Health District Office in coordinating the polio surveillance systems. Likewise, we want to acknowledge the contribution of the Israeli Polio National Certification Committee for overseeing this event. We also want to thank the “Hagihon company LTD” for their great help in increasing of wastewater sampling in the Jerusalem region.

Publisher Copyright:
© 2022 European Centre for Disease Prevention and Control (ECDC). All rights reserved.

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10.2807/1560-7917.ES.2022.27.37.2200694

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Zuckerman, N. S., Bar-Or, I., Sofer, D., Bucris, E., Morad, H., Shulman, L. M., Levi, N., Weiss, L., Aguvaev, I., Cohen, Z., Kestin, K., Vasserman, R., Elul, M., Fratty, I. S., Geva, M., Wax, M., Erster, O., Yishai, R., Hecht-Sagie, L., ... Weil, M. (2022). Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022. Eurosurveillance, 27(37), Article 2200694. https://doi.org/10.2807/1560-7917.ES.2022.27.37.2200694

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title = "Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022",

abstract = "We report an emergence and increase in poliovirus type 2 detection via routine wastewater surveillance in three non-overlapping regions in the Jerusalem region, Israel, between April and July 2022. Sequencing showed genetic linkage among isolates and accumulation of mutations over time, with two isolates defined as vaccine-derived polioviruses (VDPV). This demonstrates the emergence and potential circulation of type 2 VDPV in a high-income country with high vaccine coverage and underscores the importance of routine wastewater surveillance during the polio eradication.",

author = "Zuckerman, {Neta S.} and Itay Bar-Or and Danit Sofer and Efrat Bucris and Hagar Morad and Shulman, {Lester M.} and Nofar Levi and Leah Weiss and Irina Aguvaev and Zvi Cohen and Klil Kestin and Rinat Vasserman and Michal Elul and Fratty, {Ilana S.} and Miranda Geva and Marina Wax and Oran Erster and Ruth Yishai and Lior Hecht-Sagie and Sharon Alroy-Preis and Ella Mendelson and Merav Weil",

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Zuckerman, NS, Bar-Or, I, Sofer, D, Bucris, E, Morad, H, Shulman, LM, Levi, N, Weiss, L, Aguvaev, I, Cohen, Z, Kestin, K, Vasserman, R, Elul, M, Fratty, IS, Geva, M, Wax, M, Erster, O, Yishai, R, Hecht-Sagie, L, Alroy-Preis, S, Mendelson, E & Weil, M 2022, 'Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022', Eurosurveillance, vol. 27, no. 37, 2200694. https://doi.org/10.2807/1560-7917.ES.2022.27.37.2200694

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AU - Zuckerman, Neta S.

AU - Bar-Or, Itay

AU - Sofer, Danit

AU - Bucris, Efrat

AU - Morad, Hagar

AU - Shulman, Lester M.

AU - Levi, Nofar

AU - Weiss, Leah

AU - Aguvaev, Irina

AU - Cohen, Zvi

AU - Kestin, Klil

AU - Vasserman, Rinat

AU - Elul, Michal

AU - Fratty, Ilana S.

AU - Geva, Miranda

AU - Wax, Marina

AU - Erster, Oran

AU - Yishai, Ruth

AU - Hecht-Sagie, Lior

AU - Alroy-Preis, Sharon

AU - Mendelson, Ella

AU - Weil, Merav

PY - 2022/9/15

Y1 - 2022/9/15

N2 - We report an emergence and increase in poliovirus type 2 detection via routine wastewater surveillance in three non-overlapping regions in the Jerusalem region, Israel, between April and July 2022. Sequencing showed genetic linkage among isolates and accumulation of mutations over time, with two isolates defined as vaccine-derived polioviruses (VDPV). This demonstrates the emergence and potential circulation of type 2 VDPV in a high-income country with high vaccine coverage and underscores the importance of routine wastewater surveillance during the polio eradication.

AB - We report an emergence and increase in poliovirus type 2 detection via routine wastewater surveillance in three non-overlapping regions in the Jerusalem region, Israel, between April and July 2022. Sequencing showed genetic linkage among isolates and accumulation of mutations over time, with two isolates defined as vaccine-derived polioviruses (VDPV). This demonstrates the emergence and potential circulation of type 2 VDPV in a high-income country with high vaccine coverage and underscores the importance of routine wastewater surveillance during the polio eradication.

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Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022

Abstract

Bibliographical note

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