Embryonic and adult expression patterns of the Tec tyrosine kinase gene suggest a role in megakaryocytopoiesis, blood vessel development, and melanogenesis

Michael Klüppel, Dorit B. Donoviel, Mary E. Brunkow, Benny Motro, Alan Bernstein

    Research output: Contribution to journalArticlepeer-review

    5 Scopus citations

    Abstract

    The Tec cytoplasmic tyrosine kinase is a member of a family of src-like proteins that are thought to play important roles in hematopoiesis. Here we describe the temporal and spatial expression of the Tec gene during embryogenesis and in the adult. Our data demonstrate that embryonic Tec expression is restricted to distinct hematopoietic cells as well as structures and cell types that share a common feature of containing fluid in an enclosed cavity, e.g., endothelial cells. In addition, Tec is expressed in melanocytes late in gestation. The observed developmental expression pattern of Tec suggests a role for this gene in several aspects of hematopoiesis and/or blood vessel development as well as in late stages of melanogenesis.

    Original languageEnglish
    Pages (from-to)1249-1256
    Number of pages8
    JournalCell Growth and Differentiation
    Volume8
    Issue number12
    StatePublished - Dec 1997

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