Embryonal germ-layer antigens: target for autoimmunity

B. Tadmor, Y. Naparstek, C. Putterman

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Histopathological analysis of some systemic autoimmune diseases and syndromes led us to the conclusion that the common feature of the organs involved might be their embryonal origin. We suggest that organs derived from the same germ layer express common germ-layer-specific antigens. Such antigens could serve as target antigens for the autoimmune response.

Original languageEnglish
Pages (from-to)975-978
Number of pages4
JournalThe Lancet
Issue number8799
StatePublished - 18 Apr 1992
Externally publishedYes

Bibliographical note

Funding Information:
We thank all clinicians and pathologists who provide data for the SMG; the Scottish Home and Health Department and the Cancer Research Campaign for financial support; and Miss Evelyn Salt and Mrs Jenny Stewart for their invaluable assistance with this project.

Funding Information:
Y. N. holds the Leifferman Chair m Arthritis. This study was supported by the Gablinger Fund for Research in Autoimmunity. We thank Prof I. Cohen (Weizmann Institute for Science, Rehovot) for help and suggestions in preparing the paper.


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