Elucidation of the neurobiology of depression: Insights from a novel genetic animal model

Gal Yadid, Rachel Nakash, Ilana Deri, Grin Tamar, Noa Kinor, Iris Gispan, Abraham Zangen

Research output: Contribution to journalReview articlepeer-review

118 Scopus citations


Development of drugs for the effective treatment of depressive disorders requires elucidation of factors that are critical for clinically antidepressant effects. During the past 4 years, we have studied in situ neurochemical alterations in the brain that may underlie depressive behavior. This was achieved using the genetically-selected Flinders Sensitive Line (FSL) of rats (a unique animal model of depression), before and after chronic antidepressant treatment. This line of rats exhibits behavioral features characteristic of depression, and responds to chronic, but not acute, antidepressant treatments. This review summarizes our findings concerning the local neuro-dynamics in the brain during manifestation of depressive behavior and effective antidepressant treatment in this animal model of depression. Understanding the abnormalities manifested in neurochemical pathways during depressive disorders and the dynamic effects of these abnormalities on the onset of action and efficacy of pharmacological treatments are crucial for the development of effective antidepresssant drugs and therapeutic strategies. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)353-378
Number of pages26
JournalProgress in Neurobiology
Issue number4
StatePublished - 1 Nov 2000

Bibliographical note

Funding Information:
We wish to thank Dr. Overstreet, University of North Carolina for supplying FSL rats that were used to establish a colony in G.Y. laboratory. The studies presented in this review were supported in part by grants from the Susan and Leslie Gonda (Goldschmied) Foundation, LA, California, Bar-Ilan Research Foundation (No. 2520) and the National Institute for Psychobiology in Israel (No. 3299) to Gal Yadid.


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