Elevated plasma immunoreactive β-endorphin in anorexia nervosa

R. Tepper; A. Weizman; A. Apter; S. Tyano; Y. Beyth

doi:10.1097/00002826-199210000-00006

Elevated plasma immunoreactive β-endorphin in anorexia nervosa

R. Tepper
, A. Weizman
, A. Apter
, S. Tyano
, Y. Beyth

Geha Mental Health Center

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Basal morning plasma levels of immunoreactive-β-endorphin (ir-β-EP), and 17-β estradiol (E₂) were assessed in 25 adolescents with anorexia nervosa (AN) in comparison to 24 healthy controls. All subjects were drug free for at least 6 weeks. The mean plasma level of ir-β-EP was significantly higher (84%) in the AN patients when compared with the control subjects. The elevated plasma ir-β-EP may be relevant to the suppression of appetite, tolerance of fasting, and to the hypothalamic hypogonadism in AN.

Original language	English
Pages (from-to)	387-391
Number of pages	5
Journal	Clinical Neuropharmacology
Volume	15
Issue number	5
DOIs	https://doi.org/10.1097/00002826-199210000-00006
State	Published - Oct 1992
Externally published	Yes

Keywords

Anorexia nervosa
Hypogonadism
Starvation
Stress
β-Endorphin

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10.1097/00002826-199210000-00006

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abstract = "Basal morning plasma levels of immunoreactive-β-endorphin (ir-β-EP), and 17-β estradiol (E2) were assessed in 25 adolescents with anorexia nervosa (AN) in comparison to 24 healthy controls. All subjects were drug free for at least 6 weeks. The mean plasma level of ir-β-EP was significantly higher (84\%) in the AN patients when compared with the control subjects. The elevated plasma ir-β-EP may be relevant to the suppression of appetite, tolerance of fasting, and to the hypothalamic hypogonadism in AN.",

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AU - Tyano, S.

AU - Beyth, Y.

PY - 1992/10

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N2 - Basal morning plasma levels of immunoreactive-β-endorphin (ir-β-EP), and 17-β estradiol (E2) were assessed in 25 adolescents with anorexia nervosa (AN) in comparison to 24 healthy controls. All subjects were drug free for at least 6 weeks. The mean plasma level of ir-β-EP was significantly higher (84%) in the AN patients when compared with the control subjects. The elevated plasma ir-β-EP may be relevant to the suppression of appetite, tolerance of fasting, and to the hypothalamic hypogonadism in AN.

AB - Basal morning plasma levels of immunoreactive-β-endorphin (ir-β-EP), and 17-β estradiol (E2) were assessed in 25 adolescents with anorexia nervosa (AN) in comparison to 24 healthy controls. All subjects were drug free for at least 6 weeks. The mean plasma level of ir-β-EP was significantly higher (84%) in the AN patients when compared with the control subjects. The elevated plasma ir-β-EP may be relevant to the suppression of appetite, tolerance of fasting, and to the hypothalamic hypogonadism in AN.

KW - Anorexia nervosa

KW - Hypogonadism

KW - Starvation

KW - Stress

KW - β-Endorphin

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ER -

Elevated plasma immunoreactive β-endorphin in anorexia nervosa

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Keywords

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