Elevated interleukin-6 secretion levels by mononuclear cells of Alzheimer's patients

F. Shalit; B. Sredni; L. Stern; E. Kott; M. Huberman

doi:10.1016/0304-3940(94)90003-5

Elevated interleukin-6 secretion levels by mononuclear cells of Alzheimer's patients

F. Shalit, B. Sredni, L. Stern, E. Kott, M. Huberman

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Abstract

It has been suggested in recent research that interleukin-1 (IL-1) and interleukin-6 (IL-6) play a role in the pathogenesis of Alzheimer's disease (AD). Production of IL-1, by lipopolysaccharide (LPS)-stimulated monocytes, and IL-6, by phytohaemagglutinin (PHA)-stimulated mononuclear cells, was assessed in patients with AD divided into two groups - mild and moderately severe -according to severity of disease, and elderly controls. No differences in IL-1 production were found among AD patients and controls. However, significant elevation in IL-6 secretion levels was observed in both the mild and moderately severe AD patients. Our results suggest that peripheral IL-6 secretion levels may be responsible for acute-phase proteins observed in the serum of AD patients.

Original language	English
Pages (from-to)	130-132
Number of pages	3
Journal	Neuroscience Letters
Volume	174
Issue number	2
DOIs	https://doi.org/10.1016/0304-3940(94)90003-5
State	Published - 20 Jun 1994

Keywords

Acute-phase protein
Alzheimer's Disease
Cytokine
Dementia
Interleukin-1
Interleukin-6

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10.1016/0304-3940(94)90003-5

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title = "Elevated interleukin-6 secretion levels by mononuclear cells of Alzheimer's patients",

abstract = "It has been suggested in recent research that interleukin-1 (IL-1) and interleukin-6 (IL-6) play a role in the pathogenesis of Alzheimer's disease (AD). Production of IL-1, by lipopolysaccharide (LPS)-stimulated monocytes, and IL-6, by phytohaemagglutinin (PHA)-stimulated mononuclear cells, was assessed in patients with AD divided into two groups - mild and moderately severe -according to severity of disease, and elderly controls. No differences in IL-1 production were found among AD patients and controls. However, significant elevation in IL-6 secretion levels was observed in both the mild and moderately severe AD patients. Our results suggest that peripheral IL-6 secretion levels may be responsible for acute-phase proteins observed in the serum of AD patients.",

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AU - Shalit, F.

AU - Sredni, B.

AU - Stern, L.

AU - Kott, E.

AU - Huberman, M.

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Elevated interleukin-6 secretion levels by mononuclear cells of Alzheimer's patients

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