Elevated haemoglobin levels in the motor cortex following 1 Hz transcranial magnetic stimulation: A preliminary study

Tzu Ching Chiang; Tharshan Vaithianathan; Terence Leung; Michal Lavidor; Vincent Walsh; David T. Delpy

doi:10.1007/s00221-007-0952-x

Elevated haemoglobin levels in the motor cortex following 1 Hz transcranial magnetic stimulation: A preliminary study

Tzu Ching Chiang, Tharshan Vaithianathan, Terence Leung, Michal Lavidor, Vincent Walsh, David T. Delpy

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

One hertz transcranial magnetic stimulation (TMS) over the motor cortex has been reported to increase activity in the motor cortex contralateral to stimulation, as evidenced by the elevated motor evoked potential on the corresponding hand muscle. Little research, however, has assessed concomitant changes in the haemoglobin level in the unstimulated motor cortex. An aim of this study was to measure the change of oxy- and deoxy-haemoglobin levels in the left motor cortex after 20 min of 1 Hz TMS over the right motor cortex. Subjects carried out a finger to thumb tapping task sequentially with six blocks of ten cycles (30 s on and 60 s off). One block was performed before TMS and five after TMS. The results show that the level of oxyhaemoglobin in the unstimulated cortex increased after TMS over the contralateral hemisphere and that the increase lasted 40 min after 1 Hz stimulation. Deoxy-haemoglobin was slightly decreased during the first 15 min after stimulation. The results identify long term physiological changes resulting from 1 Hz stimulation and help to inform our understanding of interhemispheric interactions in TMS studies.

Original language	English
Pages (from-to)	555-560
Number of pages	6
Journal	Experimental Brain Research
Volume	181
Issue number	4
DOIs	https://doi.org/10.1007/s00221-007-0952-x
State	Published - Aug 2007
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgments We would like to thank Dr. Kai Thilo, Department of Physiology, University of Oxford, for providing the software used in the threshold procedure, and thank John Rothwell for his helpful comments. This work was supported by grants from the Wellcome trust and The Royal Society.

Funding

Acknowledgments We would like to thank Dr. Kai Thilo, Department of Physiology, University of Oxford, for providing the software used in the threshold procedure, and thank John Rothwell for his helpful comments. This work was supported by grants from the Wellcome trust and The Royal Society.

Funders	Funder number
Wellcome Trust
Royal Society

Keywords

Blood flow
Finger tapping
Haemoglobin
Motor cortex
Near infrared spectroscopy (NIRS)
Oxyhaemoglobin
Transcranial magnetic stimulation (TMS)

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10.1007/s00221-007-0952-x

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title = "Elevated haemoglobin levels in the motor cortex following 1 Hz transcranial magnetic stimulation: A preliminary study",

abstract = "One hertz transcranial magnetic stimulation (TMS) over the motor cortex has been reported to increase activity in the motor cortex contralateral to stimulation, as evidenced by the elevated motor evoked potential on the corresponding hand muscle. Little research, however, has assessed concomitant changes in the haemoglobin level in the unstimulated motor cortex. An aim of this study was to measure the change of oxy- and deoxy-haemoglobin levels in the left motor cortex after 20 min of 1 Hz TMS over the right motor cortex. Subjects carried out a finger to thumb tapping task sequentially with six blocks of ten cycles (30 s on and 60 s off). One block was performed before TMS and five after TMS. The results show that the level of oxyhaemoglobin in the unstimulated cortex increased after TMS over the contralateral hemisphere and that the increase lasted 40 min after 1 Hz stimulation. Deoxy-haemoglobin was slightly decreased during the first 15 min after stimulation. The results identify long term physiological changes resulting from 1 Hz stimulation and help to inform our understanding of interhemispheric interactions in TMS studies.",

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note = "Funding Information: Acknowledgments We would like to thank Dr. Kai Thilo, Department of Physiology, University of Oxford, for providing the software used in the threshold procedure, and thank John Rothwell for his helpful comments. This work was supported by grants from the Wellcome trust and The Royal Society.",

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AU - Lavidor, Michal

AU - Walsh, Vincent

AU - Delpy, David T.

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Elevated haemoglobin levels in the motor cortex following 1 Hz transcranial magnetic stimulation: A preliminary study

Abstract

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Keywords

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