Element (B, N, P) doped carbon dots interaction with neural cells: Promising results and future prospective

Raj Kumar; Vijay Bhooshan Kumar; Michal Marcus; Aharon Gedanken; Orit Shefi

doi:10.1117/12.2509610

Element (B, N, P) doped carbon dots interaction with neural cells: Promising results and future prospective

Raj Kumar, Vijay Bhooshan Kumar, Michal Marcus, Aharon Gedanken, Orit Shefi

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

14 Scopus citations

Abstract

Here, we report the preparation of carbon dots (CDs) and doping with different elements namely boron, nitrogen and phosphorous using facile single step hydrothermal method. We used biopolymers as the source material for CDs synthesis. The prepared carbon dots and elements (B, N and P) doped carbon dots' physicochemical properties are investigated using different analytical techniques. Several analytical characteristics such as Uv-visible spectroscopy, fluorescent spectroscopy and transmission electron microscopy confirm the doping of element into carbon dots. From DLS analysis it was found that the prepared carbon dots are range from 3-9 nm. Excitation dependent fluorescence with high quantum yields for B and N doped CDs showed 47% and 44%, respectively. The doped CDs impact on cell viability was investigated against neuronal PC12 cells. Interestingly, the prepared carbon dots did not affect the differentiation process of neuronal cells. Hence, the highly fluorescent CDs can be served as excellent materials for neural tissue engineering as well as biomedical engineering applications.

Original language	English
Title of host publication	Colloidal Nanoparticles for Biomedical Applications XIV
Editors	Marek Osinski, Wolfgang J. Parak
Publisher	SPIE
ISBN (Electronic)	9781510624269
DOIs	https://doi.org/10.1117/12.2509610
State	Published - 2019
Event	Colloidal Nanoparticles for Biomedical Applications XIV 2019 - San Francisco, United States Duration: 2 Feb 2019 → 4 Feb 2019

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	10892
ISSN (Print)	1605-7422

Conference

Conference	Colloidal Nanoparticles for Biomedical Applications XIV 2019
Country/Territory	United States
City	San Francisco
Period	2/02/19 → 4/02/19

Bibliographical note

Funding Information:
Dr. Raj Kumar is thankful to the Council of Higher Education for awarding PBC postdoctoral fellowship. The authors gratefully acknowledge the Bar-Ilan Institute for Nanotechnology and Advanced Materials (BINA) and Bar-Ilan University for providing infrastructure. This work was supported by the Israel Science Foundation Individual grant #1053/15 (O.S.).

Publisher Copyright:
© 2019 SPIE.

Keywords

Biocompatibility
Carbon dots
Differentiation
Fluorescence
Nanoparticle
Neural outgrowth
Neural tissue engineering

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Kumar, R., Kumar, V. B., Marcus, M., Gedanken, A., & Shefi, O. (2019). Element (B, N, P) doped carbon dots interaction with neural cells: Promising results and future prospective. In M. Osinski, & W. J. Parak (Eds.), Colloidal Nanoparticles for Biomedical Applications XIV Article 1089214 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10892). SPIE. https://doi.org/10.1117/12.2509610

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title = "Element (B, N, P) doped carbon dots interaction with neural cells: Promising results and future prospective",

abstract = "Here, we report the preparation of carbon dots (CDs) and doping with different elements namely boron, nitrogen and phosphorous using facile single step hydrothermal method. We used biopolymers as the source material for CDs synthesis. The prepared carbon dots and elements (B, N and P) doped carbon dots' physicochemical properties are investigated using different analytical techniques. Several analytical characteristics such as Uv-visible spectroscopy, fluorescent spectroscopy and transmission electron microscopy confirm the doping of element into carbon dots. From DLS analysis it was found that the prepared carbon dots are range from 3-9 nm. Excitation dependent fluorescence with high quantum yields for B and N doped CDs showed 47% and 44%, respectively. The doped CDs impact on cell viability was investigated against neuronal PC12 cells. Interestingly, the prepared carbon dots did not affect the differentiation process of neuronal cells. Hence, the highly fluorescent CDs can be served as excellent materials for neural tissue engineering as well as biomedical engineering applications.",

keywords = "Biocompatibility, Carbon dots, Differentiation, Fluorescence, Nanoparticle, Neural outgrowth, Neural tissue engineering",

author = "Raj Kumar and Kumar, {Vijay Bhooshan} and Michal Marcus and Aharon Gedanken and Orit Shefi",

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Kumar, R, Kumar, VB, Marcus, M, Gedanken, A & Shefi, O 2019, Element (B, N, P) doped carbon dots interaction with neural cells: Promising results and future prospective. in M Osinski & WJ Parak (eds), Colloidal Nanoparticles for Biomedical Applications XIV., 1089214, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 10892, SPIE, Colloidal Nanoparticles for Biomedical Applications XIV 2019, San Francisco, United States, 2/02/19. https://doi.org/10.1117/12.2509610

Element (B, N, P) doped carbon dots interaction with neural cells: Promising results and future prospective. / Kumar, Raj; Kumar, Vijay Bhooshan; Marcus, Michal et al.
Colloidal Nanoparticles for Biomedical Applications XIV. ed. / Marek Osinski; Wolfgang J. Parak. SPIE, 2019. 1089214 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10892).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Kumar, Raj

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AU - Gedanken, Aharon

AU - Shefi, Orit

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N2 - Here, we report the preparation of carbon dots (CDs) and doping with different elements namely boron, nitrogen and phosphorous using facile single step hydrothermal method. We used biopolymers as the source material for CDs synthesis. The prepared carbon dots and elements (B, N and P) doped carbon dots' physicochemical properties are investigated using different analytical techniques. Several analytical characteristics such as Uv-visible spectroscopy, fluorescent spectroscopy and transmission electron microscopy confirm the doping of element into carbon dots. From DLS analysis it was found that the prepared carbon dots are range from 3-9 nm. Excitation dependent fluorescence with high quantum yields for B and N doped CDs showed 47% and 44%, respectively. The doped CDs impact on cell viability was investigated against neuronal PC12 cells. Interestingly, the prepared carbon dots did not affect the differentiation process of neuronal cells. Hence, the highly fluorescent CDs can be served as excellent materials for neural tissue engineering as well as biomedical engineering applications.

AB - Here, we report the preparation of carbon dots (CDs) and doping with different elements namely boron, nitrogen and phosphorous using facile single step hydrothermal method. We used biopolymers as the source material for CDs synthesis. The prepared carbon dots and elements (B, N and P) doped carbon dots' physicochemical properties are investigated using different analytical techniques. Several analytical characteristics such as Uv-visible spectroscopy, fluorescent spectroscopy and transmission electron microscopy confirm the doping of element into carbon dots. From DLS analysis it was found that the prepared carbon dots are range from 3-9 nm. Excitation dependent fluorescence with high quantum yields for B and N doped CDs showed 47% and 44%, respectively. The doped CDs impact on cell viability was investigated against neuronal PC12 cells. Interestingly, the prepared carbon dots did not affect the differentiation process of neuronal cells. Hence, the highly fluorescent CDs can be served as excellent materials for neural tissue engineering as well as biomedical engineering applications.

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KW - Differentiation

KW - Fluorescence

KW - Nanoparticle

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PB - SPIE

Y2 - 2 February 2019 through 4 February 2019

ER -

Element (B, N, P) doped carbon dots interaction with neural cells: Promising results and future prospective

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