Element (B, N, P) doped carbon dots interaction with neural cells: Promising results and future prospective

Raj Kumar, Vijay Bhooshan Kumar, Michal Marcus, Aharon Gedanken, Orit Shefi

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

14 Scopus citations


Here, we report the preparation of carbon dots (CDs) and doping with different elements namely boron, nitrogen and phosphorous using facile single step hydrothermal method. We used biopolymers as the source material for CDs synthesis. The prepared carbon dots and elements (B, N and P) doped carbon dots' physicochemical properties are investigated using different analytical techniques. Several analytical characteristics such as Uv-visible spectroscopy, fluorescent spectroscopy and transmission electron microscopy confirm the doping of element into carbon dots. From DLS analysis it was found that the prepared carbon dots are range from 3-9 nm. Excitation dependent fluorescence with high quantum yields for B and N doped CDs showed 47% and 44%, respectively. The doped CDs impact on cell viability was investigated against neuronal PC12 cells. Interestingly, the prepared carbon dots did not affect the differentiation process of neuronal cells. Hence, the highly fluorescent CDs can be served as excellent materials for neural tissue engineering as well as biomedical engineering applications.

Original languageEnglish
Title of host publicationColloidal Nanoparticles for Biomedical Applications XIV
EditorsMarek Osinski, Wolfgang J. Parak
ISBN (Electronic)9781510624269
StatePublished - 2019
EventColloidal Nanoparticles for Biomedical Applications XIV 2019 - San Francisco, United States
Duration: 2 Feb 20194 Feb 2019

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceColloidal Nanoparticles for Biomedical Applications XIV 2019
Country/TerritoryUnited States
CitySan Francisco

Bibliographical note

Funding Information:
Dr. Raj Kumar is thankful to the Council of Higher Education for awarding PBC postdoctoral fellowship. The authors gratefully acknowledge the Bar-Ilan Institute for Nanotechnology and Advanced Materials (BINA) and Bar-Ilan University for providing infrastructure. This work was supported by the Israel Science Foundation Individual grant #1053/15 (O.S.).

Publisher Copyright:
© 2019 SPIE.


  • Biocompatibility
  • Carbon dots
  • Differentiation
  • Fluorescence
  • Nanoparticle
  • Neural outgrowth
  • Neural tissue engineering


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