Electrodeposited Phosphorous-Doped Graphitic Carbon Nitride as A Versatile Metal Free Interface for Tryptophan Detection in Dietary, Nutritional, and Clinical Samples

Ankush Kumar Singh, Tarul, Abhinav Pratap Singh Bais, Rosy

Research output: Contribution to journalArticlepeer-review

Abstract

Tryptophan (TRP) is an essential amino acid that is crucial for human growth and must be obtained through a dietary source or nutritional supplements. Both, the overconsumption or deficiency induces clinical symptoms. Therefore, a sensitive and selective method for quantifying TRP in dietary products, nutritional supplements, and clinical samples is essential. In this work, we have electrodeposited phosphorous doped graphitic carbon nitride (P-gCN) for developing a TRP voltammetric sensor. Outlining the benefits of electrodeposition over drop-casting, the developed P-gCN | GCE sensor demonstrated 7.83 times more sensitivity and a negative shift of ∼0.10 V for TRP electro-oxidation compared to unmodified electrode implying its remarkable electrocatalytic activity. The sensor featured a detection-limit of 7.1 nM and showcased excellent stability, repeatability and reproducibility. The practical utility of the sensor was manifested by estimating TRP in over 12 real samples including, food products, nutritional supplements and clinical samples (urine and human blood serum).

Original languageEnglish
Article number110833
JournalMicrochemical Journal
Volume203
DOIs
StatePublished - Aug 2024
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2024 Elsevier B.V.

Keywords

  • Electrodeposition
  • Graphitic carbon nitride
  • Non-metal doping
  • Red phosphorous
  • Tryptophan
  • Voltammetric sensor

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