Electric stimulation regulates the level of Ca-channels in chick muscle culture

Michal Freud-Silverberg, Asher Shainberg

    Research output: Contribution to journalArticlepeer-review

    12 Scopus citations

    Abstract

    To examine the role of muscle activity in the expression of 1,4-dihydropyridine (DHP)-sensitive Ca-channels, we electrically stimulated chick skeletal muscle cells growing in culture. The number of Ca-channels was determined by a radioligand binding technique using [3H]PN200-110. The function of these channels was measured by depolarization-induced 45Ca uptake. We found that both the amount and the function of these channels were higher as a result of the increased muscle activity caused by electrical stimulation (ES).

    Original languageEnglish
    Pages (from-to)104-106
    Number of pages3
    JournalNeuroscience Letters
    Volume151
    Issue number1
    DOIs
    StatePublished - 5 Mar 1993

    Bibliographical note

    Funding Information:
    This work wasp artiallys upportedb y fundsf rom Otto Meyerhoff Drug ReceptorC enter and from the Health ScienceR esearchC entera t Bar-Ban University.W e are indebtedt o Ms. T. Zinman and A. Isaac for their valuable technicala ssistancea nd to A. Goldreich for typing the manuscript.

    Funding

    This work wasp artiallys upportedb y fundsf rom Otto Meyerhoff Drug ReceptorC enter and from the Health ScienceR esearchC entera t Bar-Ban University.W e are indebtedt o Ms. T. Zinman and A. Isaac for their valuable technicala ssistancea nd to A. Goldreich for typing the manuscript.

    FundersFunder number
    Health ScienceR esearchC entera t Bar-Ban University.W e
    Otto Meyerhoff Drug ReceptorC

      Keywords

      • Ca-channel
      • DHP receptor
      • Electric stimulation
      • Muscle culture

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