Effort-based decision making in schizophrenia: Evaluation of paradigms to measure motivational deficits

Michael F. Green, William P. Horan

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Effort-based decision making requires one to decide how much effort to expend for a certain amount of reward. As the amount of reward goes up most people are willing to exert more effort. This relationship between reward level and effort expenditure can be measured in specialized performance-based tasks that have only recently been applied to schizophrenia. Such tasks provide a way to measure objectively motivational deficits in schizophrenia, which now are only assessed with clinical interviews of negative symptoms. The articles in this theme provide reviews of the relevant animal and human literatures (first 2 articles), and then a psychometric evaluation of 5 effort-based decision making paradigms (last 2 articles). This theme section is intended to stimulate interest in this emerging area among basic scientists developing paradigms for preclinical studies, human experimentalists trying to disentangle factors that contribute to performance on effort-based tasks, and investigators looking for objective endpoints for clinical trials of negative symptoms in schizophrenia.

Original languageEnglish
Pages (from-to)1021-1023
Number of pages3
JournalSchizophrenia Bulletin
Volume41
Issue number5
DOIs
StatePublished - Sep 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Author 2015. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.

Keywords

  • Effort-based decision making
  • Motivation
  • Negative symptoms

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