Efficacy of a mucoadhesive patch compared with an oral solution for treatment of aphthous stomatitis

Avner Shemer, Boaz Amichai, Henri Trau, Nir Nathansohn, Boaz Mizrahi, Abraham J. Domb

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Objective: The purpose of this study was to evaluate the efficacy and tolerability of a mucoadhesive patch compared with a pain-relieving oral solution for the treatment of aphthous stomatitis. Methods: Patients with active aphthous stomatitis were randomly treated either once a day with a mucoadhesive patch containing citrus oil and magnesium salts (n = 26) or three times a day with an oral solution containing benzocaine and compound benzoin tincture (n = 22). All patients were instructed to apply the medication until pain had resolved, and completed a questionnaire detailing multiple clinical parameters followed by an evaluation of the treatment. Results: The mucoadhesive patch was found to be more effective than the oral solution in terms of healing time (mean ± SD: 36.0 ± 22.8 hours vs 134.7 ± 57.7, p < 0.001) and pain intensity after 12 and 24 hours (3.7 ± 2.8 vs 6.3 ± 2.6, p = 0.003, and 2.3 ± 2.7 vs 5.7 ± 2.5, p < 0.001, respectively). Local adverse effects 1 hour after treatment were significantly (p < 0.01) less frequent among the mucoadhesive patch patients compared with the oral solution patients. Conclusions: The mucoadhesive patch was found to be significantly more effective and better tolerated than the oral solution in the treatment of aphthous stomatitis.

Original languageEnglish
Pages (from-to)29-35
Number of pages7
JournalDrugs in R and D
Volume9
Issue number1
DOIs
StatePublished - 2008
Externally publishedYes

Keywords

  • Aphthous ulcer, treatment
  • Drug delivery systems

Fingerprint

Dive into the research topics of 'Efficacy of a mucoadhesive patch compared with an oral solution for treatment of aphthous stomatitis'. Together they form a unique fingerprint.

Cite this