Effects of wear particles from metallic implant materials on the pro-inflammatory state of endothelial cells in vitro

K. Peters, D. R. Haynes, T. N. Crotti, R. E. Unger, C. J. Kirkpatrick

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The effects that different metallic particles have on human microvascular endothelial cells (EC) were analyzed by in vitro study. Particle-induced phenotypic changes, cytotoxicity and the effects on expression of pro-inflammatory surface molecules were studied by electron microscopy, cytotoxicity assays and immunoassays. All particle-types were internalized by human dermal microvascular EC (HDMEC) within 24 hours incubation time. It was shown that the expression of E-selectin was reduced after CoCr-particle exposure in a concentration-dependent manner compared to the untreated control.

Original languageEnglish
Title of host publicationTransactions - 7th World Biomaterials Congress
Pages1150
Number of pages1
StatePublished - 2004
Externally publishedYes
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: 17 May 200421 May 2004

Publication series

NameTransactions - 7th World Biomaterials Congress

Conference

ConferenceTransactions - 7th World Biomaterials Congress
Country/TerritoryAustralia
CitySydney
Period17/05/0421/05/04

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