Effects of vasopressor administration on the outcomes of microsurgical breast reconstruction

Chen Chen, Minh Doan Nguyen, Eran Bar-Meir, Philip A. Hess, Samuel Lin, Adam M. Tobias, Joseph Upton, Bernard T. Lee

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


The use of vasopressors during microsurgery is still debated. General anesthesia often induces hypotension, but microsurgeons are reluctant to use intraoperative vasopressors with the potential risks of vasoconstriction. A retrospective review was performed on 187 consecutive patients undergoing 258 deep inferior pigastric perforator flaps, free transverse rectus abdominis myocutaneous flap, and muscle-sparing free transverse rectus abdominis myocutaneous flap operations. A total of 102 patients (140 flaps) received intraoperative ephedrine and/or phenylephrine and 85 patients (118 flaps) did not. The administration of vasopressors did not affect the rates of reoperation, complete flap loss, partial flap loss, or fat necrosis. Patients receiving vasopressors had no differences in operative time, number of perforators, or number of rows of perforators harvested. There was no statistically significant association between dosage, timing, and complications. Although we do not recommend routine vasopressor use during microsurgery, administration does not seem to increase complications in microsurgical breast reconstruction.

Original languageEnglish
Pages (from-to)28-31
Number of pages4
JournalAnnals of Plastic Surgery
Issue number1
StatePublished - Jul 2010
Externally publishedYes


  • breast reconstruction
  • flap loss
  • microsurgery
  • vasopressors


Dive into the research topics of 'Effects of vasopressor administration on the outcomes of microsurgical breast reconstruction'. Together they form a unique fingerprint.

Cite this