TY - JOUR
T1 - Effects of trh implants in proximity to trigeminal motoneurons upon the craniofacial complex
AU - Byrd, K. E.
AU - Dowlinq, J. R.
AU - Sukav, M. J.
AU - Thorne, G. D.
AU - Domb, A. J.
PY - 1996
Y1 - 1996
N2 - The hypothesis that delivery of thyrotropinreleasing hormone (TRH) in proximity to trigeminal motoneurons (TMNe) can alter craniofacial growth of growing rats was tested by implanting biodegradable polyanhydride microspheres (Mathiowitz et al., 1988; Byrd et al., 1992; Byrd and Hamilton-Byrd, 1994) containing 10% TRH (Bachern, CA) approximately 900 m rostral to left-side TMNu in 10 35-day old male, Sprague-Dawley rats. Blank microsphere (10 rats) and sham (10 rats) procedures were also performed in control rats of identical age; TRH, blank, and sham rats were killed at 14 and 21 days postop for brain histology and dissection. Compared to blanks and shams, TRH rats showed significantly (p<0.05,0.01) larger weights (x±sd g) for the masseter, temporalis, anterior digastric, medial pterygoid, and lateral pterygoid muscles; TRH rats also had alterations of the facial skeleton and TMJ region with longer implant-side glenoid fossae and altered TMJ discs. Increased stimulation of TMNe by TRH is the postulated mechanism for the observed seauelae.
AB - The hypothesis that delivery of thyrotropinreleasing hormone (TRH) in proximity to trigeminal motoneurons (TMNe) can alter craniofacial growth of growing rats was tested by implanting biodegradable polyanhydride microspheres (Mathiowitz et al., 1988; Byrd et al., 1992; Byrd and Hamilton-Byrd, 1994) containing 10% TRH (Bachern, CA) approximately 900 m rostral to left-side TMNu in 10 35-day old male, Sprague-Dawley rats. Blank microsphere (10 rats) and sham (10 rats) procedures were also performed in control rats of identical age; TRH, blank, and sham rats were killed at 14 and 21 days postop for brain histology and dissection. Compared to blanks and shams, TRH rats showed significantly (p<0.05,0.01) larger weights (x±sd g) for the masseter, temporalis, anterior digastric, medial pterygoid, and lateral pterygoid muscles; TRH rats also had alterations of the facial skeleton and TMJ region with longer implant-side glenoid fossae and altered TMJ discs. Increased stimulation of TMNe by TRH is the postulated mechanism for the observed seauelae.
UR - http://www.scopus.com/inward/record.url?scp=33749307792&partnerID=8YFLogxK
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AN - SCOPUS:33749307792
SN - 0892-6638
VL - 10
SP - A765
JO - FASEB Journal
JF - FASEB Journal
IS - 3
ER -