Abstract
TRH and PS-24 (a TRH peptidase resistant analogue) induce different effects on body temperature and motor activity in rats kept at 4°C. PS-24 induced hypothermia, but TRH did not. PS-24 induced hypermotility, while TRH induced slight hypomotility. The thermal effect of TRH in hypophysectomized rats was similar to its effect in control intact rats, but PS-24 induced marked hypothermia in hypophysectomized rats. While TRH partially blocked d-amphetamine-induced hypothermia, PS-24 potentiated it. The PS-24 hypothermic effect, as well as d-amphetamine-induced hypothermia were blocked in olfactory tubercle-lesioned rats. The data indicate that the thermal effects of PS-24 are mediated by the dopaminergic neurons in the nucleus accumbens and are reversible by pretreatment with haloperidol in hypophysectomized rats. In addition, no correlation between the effects of the treatments on thermoregulation and motor activity was found.
| Original language | English |
|---|---|
| Pages (from-to) | 131-135 |
| Number of pages | 5 |
| Journal | Peptides |
| Volume | 2 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1981 |
Bibliographical note
Funding Information:This work was supported in part by a grant from Chemie Gr0-nenthal CmbH, Aachen, to M.B.It.Y.
Funding
This work was supported in part by a grant from Chemie Gr0-nenthal CmbH, Aachen, to M.B.It.Y.
| Funders | Funder number |
|---|---|
| Chemie Gr0-nenthal CmbH |
Keywords
- Ambient temperature
- DA mesolimbic pathway
- Drug interaction
- Haloperidol
- Hypothermia
- TRH PS-24
- d-Amphetamine