Effects of d-amphetamine on the set point of the thermoregulatory system in rats

Shlomo Yehuda, Reuven Frommer

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Exposing a rat's tail to an ambient temperature lower than that sensed by the rest of the body causes an increase in body temperature. Pretreatment with d-amphetamine causes an even greater increase in body temperature. Moreover, while control rats perceive any ambient temperature below 20° C as 'cold', amphetamine-treated animals only perceive ambient temperatures below 20° C as "cold". This effect of d-amphetamine was found not only when the body temperature of the rats was 20° C, but also when the body was kept at ambient temperatures of 15°-4° C. Because this effect of d-amphetamine, i.e., shifting of the reference point among treated rats, was found in two other situations (behavioral thermoregulation and in studying the anorexic effects of d-amphetamine among rats kept at different ambient temperatures), the best explanation is that in addition to the effects of the drug upon some thermal sensory roles, it also causes a change in the value of the set point of the thermoregulatory system, and drug-treated rats perceive ambient temperatures of 10° C as 'normal'.

Original languageEnglish
Pages (from-to)249-252
Number of pages4
Issue number3
StatePublished - Jan 1978


  • Hypothermia
  • Set point
  • Thermoregulation
  • d-Amphetamine


Dive into the research topics of 'Effects of d-amphetamine on the set point of the thermoregulatory system in rats'. Together they form a unique fingerprint.

Cite this