Effects of compression injury on brain mitochondrial and tissue viability evaluated by a multiparametric monitoring system

Efrat Barbiro-Michaely, Galit Bachbut, Avraham Mayevsky

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Scopus citations


Neurosurgical procedures involve brain compression created by retractors. Although it is clear that retractors are causing damage to the brain tissue, the pathophysiology of the retraction was not investigated in details. In the present study we used the multiparametric monitoring approach for real time evaluation of mitochondrial function, hemodynamic, ionic and electrical activities monitored contralaterally to the retractor placement on the brain. The aims of the study were to test the effects of retractor size and severity of the compression on the degree of damage to the cerebral tissue. A special probe was lowered towards the cerebral cortex, (2mm and 4mm in depth) using a micromanipulator. Compression lasted for 30 minutes, than the retractor was elevated back to its initial position and monitoring continued for two hours. Additionally, two sizes of retractors were used 6mm and 3mm in diameter, the 3mm retractor included an intracranial pressure (ICP) probe. The results show that the combination of a large retractor with the depth of 4mm yielded high mortality rate (62%) of the rats while the use of a smaller retractor decreased significantly the percentage of mortality. Also, compression to the depth of 4mm increased tissue injury as compared to 2mm depth. In conclusion, the present study raises the importance and significance of multiparametric monitoring, and not only ICP and cerebral blood flow of the areas nearby the retractor position and not only the retraction site, as well as the effect of the retractor size on the damage induced to the cerebral tissue.

Original languageEnglish
Title of host publicationAdvanced Biomedical and Clinical Diagnostic Systems VI
StatePublished - 2008
EventAdvanced Biomedical and Clinical Diagnostic Systems VI - San Jose, CA, United States
Duration: 20 Jan 200821 Jan 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceAdvanced Biomedical and Clinical Diagnostic Systems VI
Country/TerritoryUnited States
CitySan Jose, CA


  • Cerebral blood flow
  • Contralateral brain monitoring
  • Mitochondrial function
  • Retraction


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