Abstract
The effects of incubation of cultured rat skeletal myotubes in ouabain were studied on the number of [3H]ouabain binding sites and electrogenic component of membrane potential. Ouabain treatment for 2-6 days increased the number of binding sites, resting membrane potential (Em) and the ouabain-sensitive component of Em in the muscle cells. The findings strengthen the idea that Na, K-ATPase has an important role in regulation of Em in cultured skeletal muscle and suggest that Na-K pump inhibition during development may be a regulatory mechanism for cellular synthesis of Na, K-ATPase.
| Original language | English |
|---|---|
| Pages (from-to) | 121-123 |
| Number of pages | 3 |
| Journal | Brain Research |
| Volume | 347 |
| Issue number | 1 |
| DOIs | |
| State | Published - 11 Nov 1985 |
Bibliographical note
Funding Information:study was supported by funds from the Research Authority, Bar-Ilan University and Yad Hanadiv, Tel-Aviv, Israel.
Keywords
- Na, K-ATPase
- cultured skeletal myotube
- membrane potential
- ouabain binding site