Abstract
Rapid and effective wound healing requires a coordinated cellular response involving fibroblasts, keratinocytes and vascular endothelial cells (VECs). Impaired wound healing can result in multiple adverse health outcomes and, although antibiotics can forestall infection, treatments that accelerate wound healing are lacking. We now report that topical application of water soluble cerium oxide nanoparticles (Nanoceria) accelerates the healing of full-thickness dermal wounds in mice by a mechanism that involves enhancement of the proliferation and migration of fibroblasts, keratinocytes and VECs. The Nanoceria penetrated into the wound tissue and reduced oxidative damage to cellular membranes and proteins, suggesting a therapeutic potential for topical treatment of wounds with antioxidant nanoparticles.
| Original language | English |
|---|---|
| Pages (from-to) | 2194-2201 |
| Number of pages | 8 |
| Journal | Biomaterials |
| Volume | 34 |
| Issue number | 9 |
| DOIs | |
| State | Published - Mar 2013 |
Bibliographical note
Funding Information:This research was supported by the National Institute on Aging Intramural Research Program of the NIH . SS acknowledges the grant from National Science Foundation (NIRT: CBET) for funding the nanotechnology research.
Funding
This research was supported by the National Institute on Aging Intramural Research Program of the NIH . SS acknowledges the grant from National Science Foundation (NIRT: CBET) for funding the nanotechnology research.
| Funders | Funder number |
|---|---|
| NIRT | |
| National Science Foundation | |
| National Institutes of Health | |
| National Institute on Aging | ZIAAG000324 |
| Division of Chemical, Bioengineering, Environmental, and Transport Systems |
Keywords
- Cerium oxide nanoparticles
- Fibroblasts
- Keratinocytes
- Oxidative stress
- Vascular endothelial cells
- Wound healing