Effects of cerium oxide nanoparticles on the growth of keratinocytes, fibroblasts and vascular endothelial cells in cutaneous wound healing

Srinivasulu Chigurupati, Mohamed R. Mughal, Eitan Okun, Soumen Das, Amit Kumar, Michael McCaffery, Sudipta Seal, Mark P. Mattson

Research output: Contribution to journalArticlepeer-review

289 Scopus citations

Abstract

Rapid and effective wound healing requires a coordinated cellular response involving fibroblasts, keratinocytes and vascular endothelial cells (VECs). Impaired wound healing can result in multiple adverse health outcomes and, although antibiotics can forestall infection, treatments that accelerate wound healing are lacking. We now report that topical application of water soluble cerium oxide nanoparticles (Nanoceria) accelerates the healing of full-thickness dermal wounds in mice by a mechanism that involves enhancement of the proliferation and migration of fibroblasts, keratinocytes and VECs. The Nanoceria penetrated into the wound tissue and reduced oxidative damage to cellular membranes and proteins, suggesting a therapeutic potential for topical treatment of wounds with antioxidant nanoparticles.

Original languageEnglish
Pages (from-to)2194-2201
Number of pages8
JournalBiomaterials
Volume34
Issue number9
DOIs
StatePublished - Mar 2013

Bibliographical note

Funding Information:
This research was supported by the National Institute on Aging Intramural Research Program of the NIH . SS acknowledges the grant from National Science Foundation (NIRT: CBET) for funding the nanotechnology research.

Keywords

  • Cerium oxide nanoparticles
  • Fibroblasts
  • Keratinocytes
  • Oxidative stress
  • Vascular endothelial cells
  • Wound healing

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