Controls of the independent ingestion of food in the preweanling rat emerge in the second postnatal week. We investigated the effects of CCK-8 (0, 1, 5, or 10 μg/kg IP) on intake and c-Fos-like immunoreactive (CFLI) cells in hindbrain and forebrain on postnatal days 10 and 11. Five micrograms per kilogram decreased intake and increased the number of CFLI cells in four subnuclei of the nucleus tractus solitarius (NTS), in arcuate nucleus (ARC), and in central nucleus of the amygdala (CeA). Ten micrograms per kilogram decreased intake and increased CFLI in three NTS subnuclei as much as 5 μg/kg did, but was more potent than 5 μg/kg in the medial NTS subnucleus. Ten micrograms per kilogram increased CFLI in paraventricular (PVN) and supraoptic (SON) nuclei, but 5 μg/kg did not. Thus, reduction of intake by CCK-8 on days 10 and 11 is associated with increased hindbrain and forebrain CFLI.
|Number of pages||9|
|State||Published - Nov 2006|
Bibliographical noteFunding Information:
Supported by grants from the National Institutes of Health (GPS) and the US-Israel Binational Research foundation (AW & GPS). OM was supported by a President's fellowship, Bar-Ilan University. Research in AW's lab is partially supported by the Paula Rich Foundation, Bar-Ilan University.
- Independent ingestion
- Ontogeny of food intake