Effects of CCK-8 on independent ingestion and central c-Fos-like immunoreactivity in rats on postnatal days 10 and 11

S. Blumberg; M. Schroeder; D. Haba; O. Malkesman; A. M. Torregrossa; A. Weller; G. P. Smith

doi:10.1016/j.peptides.2006.05.024

Effects of CCK-8 on independent ingestion and central c-Fos-like immunoreactivity in rats on postnatal days 10 and 11

S. Blumberg, M. Schroeder, D. Haba, O. Malkesman, A. M. Torregrossa, A. Weller, G. P. Smith

Department of Psychology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Controls of the independent ingestion of food in the preweanling rat emerge in the second postnatal week. We investigated the effects of CCK-8 (0, 1, 5, or 10 μg/kg IP) on intake and c-Fos-like immunoreactive (CFLI) cells in hindbrain and forebrain on postnatal days 10 and 11. Five micrograms per kilogram decreased intake and increased the number of CFLI cells in four subnuclei of the nucleus tractus solitarius (NTS), in arcuate nucleus (ARC), and in central nucleus of the amygdala (CeA). Ten micrograms per kilogram decreased intake and increased CFLI in three NTS subnuclei as much as 5 μg/kg did, but was more potent than 5 μg/kg in the medial NTS subnucleus. Ten micrograms per kilogram increased CFLI in paraventricular (PVN) and supraoptic (SON) nuclei, but 5 μg/kg did not. Thus, reduction of intake by CCK-8 on days 10 and 11 is associated with increased hindbrain and forebrain CFLI.

Original language	English
Pages (from-to)	2820-2828
Number of pages	9
Journal	Peptides
Volume	27
Issue number	11
DOIs	https://doi.org/10.1016/j.peptides.2006.05.024
State	Published - Nov 2006

Bibliographical note

Funding Information:
Supported by grants from the National Institutes of Health (GPS) and the US-Israel Binational Research foundation (AW & GPS). OM was supported by a President's fellowship, Bar-Ilan University. Research in AW's lab is partially supported by the Paula Rich Foundation, Bar-Ilan University.

Funding

Supported by grants from the National Institutes of Health (GPS) and the US-Israel Binational Research foundation (AW & GPS). OM was supported by a President's fellowship, Bar-Ilan University. Research in AW's lab is partially supported by the Paula Rich Foundation, Bar-Ilan University.

Funders	Funder number
Paula Rich Foundation
US-Israel Binational Research Foundation
National Institutes of Health
Bar-Ilan University

Keywords

Cholecystokinin
Independent ingestion
Ontogeny of food intake
Satiety
c-Fos

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10.1016/j.peptides.2006.05.024

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title = "Effects of CCK-8 on independent ingestion and central c-Fos-like immunoreactivity in rats on postnatal days 10 and 11",

abstract = "Controls of the independent ingestion of food in the preweanling rat emerge in the second postnatal week. We investigated the effects of CCK-8 (0, 1, 5, or 10 μg/kg IP) on intake and c-Fos-like immunoreactive (CFLI) cells in hindbrain and forebrain on postnatal days 10 and 11. Five micrograms per kilogram decreased intake and increased the number of CFLI cells in four subnuclei of the nucleus tractus solitarius (NTS), in arcuate nucleus (ARC), and in central nucleus of the amygdala (CeA). Ten micrograms per kilogram decreased intake and increased CFLI in three NTS subnuclei as much as 5 μg/kg did, but was more potent than 5 μg/kg in the medial NTS subnucleus. Ten micrograms per kilogram increased CFLI in paraventricular (PVN) and supraoptic (SON) nuclei, but 5 μg/kg did not. Thus, reduction of intake by CCK-8 on days 10 and 11 is associated with increased hindbrain and forebrain CFLI.",

keywords = "Cholecystokinin, Independent ingestion, Ontogeny of food intake, Satiety, c-Fos",

author = "S. Blumberg and M. Schroeder and D. Haba and O. Malkesman and Torregrossa, {A. M.} and A. Weller and Smith, {G. P.}",

note = "Funding Information: Supported by grants from the National Institutes of Health (GPS) and the US-Israel Binational Research foundation (AW & GPS). OM was supported by a President's fellowship, Bar-Ilan University. Research in AW's lab is partially supported by the Paula Rich Foundation, Bar-Ilan University.",

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AU - Blumberg, S.

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AU - Haba, D.

AU - Malkesman, O.

AU - Torregrossa, A. M.

AU - Weller, A.

AU - Smith, G. P.

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N2 - Controls of the independent ingestion of food in the preweanling rat emerge in the second postnatal week. We investigated the effects of CCK-8 (0, 1, 5, or 10 μg/kg IP) on intake and c-Fos-like immunoreactive (CFLI) cells in hindbrain and forebrain on postnatal days 10 and 11. Five micrograms per kilogram decreased intake and increased the number of CFLI cells in four subnuclei of the nucleus tractus solitarius (NTS), in arcuate nucleus (ARC), and in central nucleus of the amygdala (CeA). Ten micrograms per kilogram decreased intake and increased CFLI in three NTS subnuclei as much as 5 μg/kg did, but was more potent than 5 μg/kg in the medial NTS subnucleus. Ten micrograms per kilogram increased CFLI in paraventricular (PVN) and supraoptic (SON) nuclei, but 5 μg/kg did not. Thus, reduction of intake by CCK-8 on days 10 and 11 is associated with increased hindbrain and forebrain CFLI.

AB - Controls of the independent ingestion of food in the preweanling rat emerge in the second postnatal week. We investigated the effects of CCK-8 (0, 1, 5, or 10 μg/kg IP) on intake and c-Fos-like immunoreactive (CFLI) cells in hindbrain and forebrain on postnatal days 10 and 11. Five micrograms per kilogram decreased intake and increased the number of CFLI cells in four subnuclei of the nucleus tractus solitarius (NTS), in arcuate nucleus (ARC), and in central nucleus of the amygdala (CeA). Ten micrograms per kilogram decreased intake and increased CFLI in three NTS subnuclei as much as 5 μg/kg did, but was more potent than 5 μg/kg in the medial NTS subnucleus. Ten micrograms per kilogram increased CFLI in paraventricular (PVN) and supraoptic (SON) nuclei, but 5 μg/kg did not. Thus, reduction of intake by CCK-8 on days 10 and 11 is associated with increased hindbrain and forebrain CFLI.

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KW - Ontogeny of food intake

KW - Satiety

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Effects of CCK-8 on independent ingestion and central c-Fos-like immunoreactivity in rats on postnatal days 10 and 11

Abstract

Bibliographical note

Funding

Keywords

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