Abstract
The current study explores the therapeutic potential of Cannabidiol (CBD), a compound in the Cannabis plant, using both sexes of 2 “depressive-like” genetic models, Wistar Kyoto (WKY) and Flinders Sensitive Line (FSL) rats. Rats ingested CBD (30 mg/kg) orally. In the saccharin preference test, following a previous report of a pro-hedonic effect of CBD in male WKY, we now found similar results in female WKY. CBD also decreased immobility in the forced swim test in males (both strains) and in female WKY. These findings suggest a role for CBD in treating mental disorders with prominent symptoms of helplessness and anhedonia.
| Original language | English |
|---|---|
| Pages (from-to) | 59-63 |
| Number of pages | 5 |
| Journal | Physiology and Behavior |
| Volume | 201 |
| DOIs | |
| State | Published - 15 Mar 2019 |
Bibliographical note
Publisher Copyright:© 2018 Elsevier Inc.
Funding
Research by RM, AW and GS is currently partially supported by Europacific Medical . This support started recently, after completion of the study reported here. The CBD preparation in RM's laboratory was supported by a donation from the Kessler Foundation , Boston. This study was supported, in part, by a grant to GS from the National Institute for Psychobiology in Israel (NIPI) the Dylan Tauber Track (Grant 159-14-15 ).
| Funders | Funder number |
|---|---|
| Europacific Medical | |
| National Institute for Psychobiology in Israel | 159-14-15 |
| Kessler Foundation |
Keywords
- Animal models of depression
- Cannabidiol
- Depression
- Flinders Sensitive Line
- Wistar- Kyoto rats