Abstract
The effect of cortical spreading depression (CSD) on oxygen demand (extracellular K+), oxygen supply (cerebral blood flow - CBF) and oxygen balance (mitochondrial NADH) was studied by a special multiprobe assembly (MPA), during hypoxia and partial ischemia. The MPA was constructed and applied to monitor the CSD wave from its front line until complete recovery, continuously and simultaneously. CSD under hypoxia or partial ischemia led to an initial increase in NADH levels and a further decrease in CBF during the first phase of the CSD wave, indicating a decrease of tissue capability to compensate for an increase in oxygen demand. Furthermore, the special design of the MPA enabled identifying the close interrelation between oxygen demand, supply and balance during CSD propagation. In conclusion, brain oxygenation was shown to have a clear effect on tissue responses to CSD. (C) 2000 Elsevier Science B.V.
| Original language | English |
|---|---|
| Pages (from-to) | 212-216 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 882 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - 3 Nov 2000 |
Bibliographical note
Funding Information:The study was supported by a grant from the Research Committee of Bar-Ilan University and the Health Sciences Research Center, the Faculty of Life Sciences, Bar-Ilan University.
Funding
The study was supported by a grant from the Research Committee of Bar-Ilan University and the Health Sciences Research Center, the Faculty of Life Sciences, Bar-Ilan University.
| Funders | Funder number |
|---|---|
| Faculty of Life Sciences | |
| Health Sciences Research Center | |
| Research Committee of Bar-Ilan University | |
| Bar-Ilan University |
Keywords
- Brain oxygenation
- Cortival spreading depression
- Extracellular K
- Hypoxia
- Ischemia
- Mitochondrial NADH